Matsuya Yuji, Sasaki Kazushige, Nagaoka Mamiko, Kakuda Hiroko, Toyooka Naoki, Imanishi Nobuko, Ochiai Hiroshi, Nemoto Hideo
Faculty of Pharmaceutical Sciences, and Department of Human Sciences and Fundamental Nursing, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
J Org Chem. 2004 Nov 12;69(23):7989-93. doi: 10.1021/jo0486995.
The synthesis and evaluation of antiviral activity of new furan-fused tetracyclic compounds are described. The syntheses were satisfactorily achieved on the basis of o-quinodimethane chemistry, using furan-containing benzocyclobutene derivatives as a substrate, in high generality and stereoselectivity. The various derivatives thus synthesized were examined on their inhibitory activity on virus growth using a hemagglutinin (HA) method, leading to a discovery of promising candidates for new antiviral drugs having high activity and good therapeutic index.
