Dumville Jo C, Lee Amanda J, Smith Felicity B, Fowkes F Gerald R
Department of Health Sciences, York, UK.
Br J Gen Pract. 2004 Nov;54(508):826-31.
Previous studies investigating the health-related quality of life of those with peripheral arterial disease have focused on patients recruited from hospital clinics. The health-related quality of life of people with peripheral arterial disease in the general population is unknown.
We aimed to determine the health-related quality of life of people with intermittent claudication and asymptomatic peripheral arterial disease in the general population and to compare it with those with angina and those with no peripheral arterial disease or angina.
Analysis of cross-sectional data from the 12-year follow-up of a population-based cohort.
Edinburgh, Scotland.
Data from the Edinburgh Artery Study cohort's 12-year follow-up was analysed. Participants' peripheral arterial disease status was measured using the World Health Organisation intermittent claudication questionnaire and the ankle brachial pressure index. Self-assessed health-related quality of life data was collected using the SF-36 generic questionnaire. Health-related quality of life scores were calculated and their associations with peripheral arterial disease status groups were tested.
Subjects with intermittent claudication had significantly worse median health-related quality of life scores than patients without claudication in all domains except social functioning and mental health. Patients with claudication had a significantly lower physical component summary score than those without claudication (P </= 0.001). This association remained after adjustment for age, sex, social class, body mass index, smoking, and angina. Those with angina and claudication had significantly worse physical component summary scores than those with no peripheral arterial disease or angina (P </= 0.001). No significant difference was found in health-related quality of life scores between those with asymptomatic peripheral arterial disease and those with no peripheral arterial disease even after multiple adjustment for confounding factors.
People with intermittent claudication in the community had impaired health-related quality of life related to reduced physical health, but asymptomatic peripheral arterial disease did not significantly affect health-related quality of life.
以往关于外周动脉疾病患者健康相关生活质量的研究主要集中在从医院诊所招募的患者。普通人群中外周动脉疾病患者的健康相关生活质量尚不清楚。
我们旨在确定普通人群中患有间歇性跛行和无症状外周动脉疾病的人的健康相关生活质量，并将其与心绞痛患者以及没有外周动脉疾病或心绞痛的人进行比较。
对基于人群的队列进行12年随访的横断面数据分析。
苏格兰爱丁堡。
分析了爱丁堡动脉研究队列12年随访的数据。使用世界卫生组织间歇性跛行问卷和踝臂压力指数测量参与者的外周动脉疾病状态。使用SF-36通用问卷收集自我评估的健康相关生活质量数据。计算健康相关生活质量得分，并测试其与外周动脉疾病状态组的关联。
除社会功能和心理健康外，间歇性跛行患者在所有领域的健康相关生活质量中位数得分均显著低于无跛行患者。跛行患者的身体成分综合得分显著低于无跛行患者（P≤0.001）。在调整年龄、性别、社会阶层、体重指数、吸烟和心绞痛后，这种关联仍然存在。患有心绞痛和跛行的患者的身体成分综合得分显著低于没有外周动脉疾病或心绞痛的患者（P≤0.001）。即使在对混杂因素进行多次调整后，无症状外周动脉疾病患者与无外周动脉疾病患者的健康相关生活质量得分也没有显著差异。
社区中患有间歇性跛行的人的健康相关生活质量因身体健康下降而受损，但无症状外周动脉疾病并未显著影响健康相关生活质量。
