Del Castillo Déjardin Daniel, Sabench Pereferrer Fàtima, Hernández González Mercè, Blanco Blasco Santiago, Abelló Sala Magda
Department of Surgery, Faculty of Medicine and Sciences, Rovira i Virgilio University, Reus (Tarragona), Spain.
Obes Surg. 2004 Oct;14(9):1263-72. doi: 10.1381/0960892042387011.
We reviewed the experimental surgery, related to bariatric surgery in laboratory animals, to consider new lines of research.
The literature on experimental surgery for morbid obesity since the mid-20th century was reviewed, focusing on existing techniques (malabsorptive, restrictive, mixed and experimental) and their associated metabolic component.
In the field of laparoscopy, there is a clear tendency for large laboratory animals such as pigs to be used. These are useful for developing and perfecting techniques. A second area of animal experimentation concentrates on the relationship between metabolism and surgery in order to find improvements in the co-morbidities associated with morbid obesity. A third area of research focuses on manipulating intake via central and vagal control.
Further studies are needed to combine traditional and recently developed techniques of experimental surgery with the mechanisms that determine the physiopathology, metabolism and regulation of intake of morbidly obese patients. To accurately determine metabolic behavior and avoid drawing conclusions that are not very significant, these studies should be carried out on obese animals and focus on the co-morbidities associated with morbid obesity.
我们回顾了与实验动物减肥手术相关的实验性手术，以思考新的研究方向。
回顾了自20世纪中叶以来有关病态肥胖实验性手术的文献，重点关注现有技术（吸收不良型、限制型、混合型和实验型）及其相关的代谢成分。
在腹腔镜领域，明显倾向于使用猪等大型实验动物。这些动物有助于开发和完善技术。动物实验的第二个领域集中在代谢与手术之间的关系，以便在与病态肥胖相关的合并症方面找到改善方法。第三个研究领域侧重于通过中枢和迷走神经控制来操纵摄入量。
需要进一步研究，将传统的和最近开发的实验性手术技术与决定病态肥胖患者生理病理学、代谢和摄入量调节的机制相结合。为了准确确定代谢行为并避免得出不太显著的结论，这些研究应在肥胖动物身上进行，并关注与病态肥胖相关的合并症。
