Davenport A T, Hodson C A
Department of Obstetrics and Gynecology, East Carolina University School of Medicine, Greenville, North Carolina 27858.
Life Sci. 1992;50(14):1001-6. doi: 10.1016/0024-3205(92)90094-6.
The effect of cyclosporin A (CsA) treatment on LH and prolactin was investigated. Chronic daily administration of an immunosuppressive dose of CsA (1.5 mg/100g bw) increased serum LH concentrations and pituitary gland LH content. CsA treatment also resulted in increased serum testosterone. Immunosuppressive doses of CsA had no effect on serum prolactin or pituitary gland prolactin content. Acute administration of low doses of 0.12, 1.2, 12 and 120ug CsA/100g bw had no effect on serum LH or prolactin. These results suggest that administration of immunosuppressive doses of CsA alters serum and pituitary LH and serum testosterone but not prolactin.
研究了环孢素A（CsA）治疗对促黄体生成素（LH）和催乳素的影响。每天慢性给予免疫抑制剂量的CsA（1.5毫克/100克体重）可提高血清LH浓度和垂体LH含量。CsA治疗还导致血清睾酮增加。免疫抑制剂量的CsA对血清催乳素或垂体催乳素含量没有影响。急性给予低剂量的0.12、1.2、12和120微克CsA/100克体重对血清LH或催乳素没有影响。这些结果表明，给予免疫抑制剂量的CsA会改变血清和垂体LH以及血清睾酮，但不会影响催乳素。
