Carreras A, Robles R, Ruiz E, Ortega E, Mendoza C, Osorio C
Brain Res Bull. 1984 Aug;13(2):339-42. doi: 10.1016/0361-9230(84)90136-9.
Serum concentrations of luteinizing hormone (LH) follicle-stimulating hormone (FSH), prolactin (PRL) and testosterone were measured by radioimmunoassay in male Wistar rats: (a) Four days after a septal lesion (n = 19) and (b) Just following electrical stimulation of the septum (n = 15). Septal lesions induced a significant decrease in serum LH (16.37 +/- 2.01 vs. 30.27 +/- 2.08 ng/ml; p less than 0.001) and testosterone concentrations (0.53 +/- 0.05 vs. 1.01 +/- 0.14 ng/ml; p less than 0.02). No significant changes were observed for FSH or PRL levels. Electrical septal stimulation induced an increase in serum levels of LH (211.5 +/- 46.4 vs. 29.6 +/- 11.5 ng/ml; p less than 0.01) and FSH (703 +/- 83 vs. 378 +/- 57 ng/ml; p less than 0.01), without changes in PRL or testosterone concentrations. From these data we conclude that in male rats the septum may play a role in the mechanisms controlling gonadotropins release by the anterior pituitary gland.
采用放射免疫分析法测定了雄性Wistar大鼠血清中促黄体生成素（LH）、促卵泡激素（FSH）、催乳素（PRL）和睾酮的浓度：（a）在进行间隔损伤4天后（n = 19）；（b）在对间隔进行电刺激后即刻（n = 15）。间隔损伤导致血清LH浓度显著降低（16.37±2.01对30.27±2.08 ng/ml；p＜0.001）以及睾酮浓度显著降低（0.53±0.05对1.01±0.14 ng/ml；p＜0.02）。FSH或PRL水平未观察到显著变化。间隔电刺激导致血清LH水平升高（211.5±46.4对29.6±11.5 ng/ml；p＜0.01）以及FSH水平升高（703±83对378±57 ng/ml；p＜0.01），而PRL或睾酮浓度无变化。从这些数据我们得出结论，在雄性大鼠中，间隔可能在控制腺垂体释放促性腺激素的机制中发挥作用。
