Carvalho Antonio Bernardo, Clark Andrew G
Departamento de Genética, Universidade Federal do Rio de Janeiro, Caixa Postal 68011, CEP 21944-970, Rio de Janeiro, Brazil.
Science. 2005 Jan 7;307(5706):108-10. doi: 10.1126/science.1101675. Epub 2004 Nov 4.
We report a genome-wide search of Y-linked genes in Drosophila pseudoobscura. All six identifiable orthologs of the D. melanogaster Y-linked genes have autosomal inheritance in D. pseudoobscura. Four orthologs were investigated in detail and proved to be Y-linked in D. guanche and D. bifasciata, which shows that less than 18 million years ago the ancestral Drosophila Y chromosome was translocated to an autosome in the D. pseudoobscura lineage. We found 15 genes and pseudogenes in the current Y of D. pseudoobscura, and none are shared with the D. melanogaster Y. Hence, the Y chromosome in the D. pseudoobscura lineage appears to have arisen de novo and is not homologous to the D. melanogaster Y.
我们报告了对拟暗果蝇Y连锁基因的全基因组搜索。黑腹果蝇Y连锁基因的所有六个可识别的直系同源基因在拟暗果蝇中都具有常染色体遗传。对四个直系同源基因进行了详细研究，结果证明它们在加那利果蝇和双带果蝇中是Y连锁的，这表明在不到1800万年前，果蝇的祖先Y染色体在拟暗果蝇谱系中易位到了常染色体上。我们在拟暗果蝇当前的Y染色体上发现了15个基因和假基因，没有一个与黑腹果蝇的Y染色体共享。因此，拟暗果蝇谱系中的Y染色体似乎是从头产生的，与黑腹果蝇的Y染色体不同源。
