自噬可保护细胞抵御A组链球菌的入侵。

Autophagy defends cells against invading group A Streptococcus.

作者信息

Nakagawa Ichiro, Amano Atsuo, Mizushima Noboru, Yamamoto Akitsugu, Yamaguchi Hitomi, Kamimoto Takahiro, Nara Atsuki, Funao Junko, Nakata Masanobu, Tsuda Kayoko, Hamada Shigeyuki, Yoshimori Tamotsu

机构信息

Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan.

出版信息

Science. 2004 Nov 5;306(5698):1037-40. doi: 10.1126/science.1103966.

DOI:10.1126/science.1103966

PMID:15528445

Abstract

We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.

摘要

我们发现自噬机制能够有效清除非吞噬细胞内的致病性A组链球菌（GAS）。GAS从内体逃逸进入细胞质后，被自噬体样区室包裹，并在这些区室与溶酶体融合时被杀死。在自噬缺陷的Atg5-/-细胞中，GAS存活、增殖并从细胞中释放出来。因此，自噬机制可作为抵御入侵病原体的先天性防御系统。