加拿大分离的百日咳博德特氏菌菌株菌毛fim3基因的多态性
Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada.
作者信息
Tsang Raymond S W, Lau Allan K H, Sill Michelle L, Halperin Scott A, Van Caeseele Paul, Jamieson Frances, Martin Irene E
机构信息
National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada R3E 3R2.
出版信息
J Clin Microbiol. 2004 Nov;42(11):5364-7. doi: 10.1128/JCM.42.11.5364-5367.2004.
Abstract
The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects.
摘要
对86株加拿大百日咳博德特氏菌分离株中编码存在于灭活全细胞疫苗和无细胞疫苗中的菌毛保护性抗原的fim基因进行了分析。发现所鉴定的至少一种新突变涉及一个已由感染或接种疫苗受试者的血清抗体定位的表面表位。
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