Elena M G, Fedele A, Gianino P, Giordanino S, Murru P, Tosi C, Vannelli S
Centro di Auxopatologia Infantile, Università di Torino.
Minerva Pediatr. 1992 Jan-Feb;44(1-2):41-2.
The aim of this study was to compare growth velocity in thalassemic children using two different treatment protocols. Thalassemic children were initially treated with high daily doses of desferrioxamine, obtaining a good rate of initial growth which then unexpectedly slowed down later. The introduction of a new treatment protocol reducing both the dose and frequency with which the drug was administered provoked a significant increase in the rate of growth greater than that observed in the group treated using the previous protocol.
本研究的目的是比较采用两种不同治疗方案的地中海贫血儿童的生长速度。地中海贫血儿童最初接受高剂量每日去铁胺治疗,初期生长率良好,但随后意外减缓。引入一种新的治疗方案,减少了药物的给药剂量和频率,结果生长率显著提高,高于采用先前方案治疗的组。