Thalhammer C, Aschwanden M, Kliem M, Stürchler M, Jäger K A
Klinik für Angiologie, Universitätsspital, Basel, Schweiz.
Dtsch Med Wochenschr. 2004 Nov 5;129(45):2405-8. doi: 10.1055/s-2004-835277.
A 36-year-old patient presented with a severe hand ischemia after intraarterial injection of four dissolved tablets of Methylphenidate each 10 mg (Ritalin into the right radial artery.
Non-invasive vascular diagnostic demonstrated a normal perfusion of the radial and ulnar artery and a severe ischemia of the small vessels of the right hand.
Under suspicion of a combined vaso-spastic and thromboembolic arterial occlusion we started an intraarterial lysis therapy followed by anticoagulation with heparin and infusions of prostaglandines. Despite this therapy necroses of three fingers developed; partial amputation was followed by a good wound healing.
Ischemia of an extremity after intraarterial injection of drugs is a vascular emergency.
一名36岁患者在经右桡动脉动脉内注射4片每片10毫克的哌甲酯（利他林）溶解片后出现严重手部缺血。
无创血管诊断显示桡动脉和尺动脉灌注正常，右手小血管严重缺血。
怀疑为血管痉挛和血栓栓塞性动脉闭塞合并，我们开始进行动脉内溶栓治疗，随后用肝素抗凝并输注前列腺素。尽管进行了这种治疗，仍有三根手指发生坏死；部分截肢后伤口愈合良好。
动脉内注射药物后肢体缺血是一种血管急症。
