Suciu Ioana, Negrean V, Sâmpelean D
4th Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Rom J Intern Med. 2004;42(2):395-406.
The diabetes mellitus occurs as an important disease at elderly people, to whom the micro- and macrovascular complications represent a major cause of morbidity and mortality. Experimental researches of the last years proved that the oxidative stress may be the common mechanisms that intervenes in the occurrence of the diabetes complications as well as in the aging process and is responsible for the increased prevalence of chronic complications at elderly diabetics. Starting from this information, we performed a comparative study where we followed the intensity of the oxidative stress at elderly diabetics as compared to adult diabetics and non-diabetic elderly people. At the same time, we have followed the involvement of oxidative stress in the occurrence of diabetic microangiopathy and atherosclerosis. 155 patients from the 4th Medical Clinic were studied during 2000-2003. These patients were divided into three lots: lot 1: elderly diabetics, lot 2: adult diabetics, lot 3: elderly non-diabetics. At these patients we have followed comparatively the intensity of the oxidant status by determining the plasma malondialdehyde (MDA) and the anti-oxidant status by determining the plasma ceruloplasmin, as well as the correlations of these two parameters with the chronic complications of diabetes. At elderly diabetics there is an increased oxidative stress underlined by an increased plasma level of MDA and ceruloplasmin as compared to the adult diabetics and non-diabetic elderly people and this increased oxidative stress is involved in the development of the chronic complications at this patients. In case of elderly diabetics, the age and the illness may induce the formation of oxygen-derived free radicals with synergic effect in injuring tissues and organs.
糖尿病是老年人中的一种重要疾病，微血管和大血管并发症是其发病和死亡的主要原因。近年来的实验研究证明，氧化应激可能是参与糖尿病并发症发生以及衰老过程的共同机制，并且是老年糖尿病患者慢性并发症患病率增加的原因。基于这一信息，我们进行了一项比较研究，追踪老年糖尿病患者与成年糖尿病患者及非糖尿病老年人相比氧化应激的强度。同时，我们追踪了氧化应激在糖尿病微血管病变和动脉粥样硬化发生中的作用。2000年至2003年期间对第四医疗诊所的155名患者进行了研究。这些患者被分为三组：第一组：老年糖尿病患者，第二组：成年糖尿病患者，第三组：老年非糖尿病患者。我们通过测定血浆丙二醛（MDA）比较了这些患者的氧化状态强度，通过测定血浆铜蓝蛋白比较了抗氧化状态，以及这两个参数与糖尿病慢性并发症的相关性。与成年糖尿病患者和非糖尿病老年人相比，老年糖尿病患者的氧化应激增加，表现为血浆MDA和铜蓝蛋白水平升高，并且这种增加的氧化应激参与了这些患者慢性并发症的发展。对于老年糖尿病患者，年龄和疾病可能协同诱导氧自由基的形成，从而损伤组织和器官。
