脂质过氧化产物、血浆总抗氧化状态以及铜锌超氧化物歧化酶活性作为老年糖尿病前期患者氧化应激生物标志物的作用。
Role of lipid peroxidation products, plasma total antioxidant status, and Cu-, Zn-superoxide dismutase activity as biomarkers of oxidative stress in elderly prediabetics.
作者信息
Dzięgielewska-Gęsiak Sylwia, Wysocka Ewa, Michalak Sławomir, Nowakowska-Zajdel Ewa, Kokot Teresa, Muc-Wierzgoń Małgorzata
机构信息
Teaching Department and Hospital Ward of Internal Diseases, Medical University of Silesia, Żeromskiego 7 Street, 41-902 Bytom, Poland.
Department of Clinical Biochemistry and Laboratory Medicine, Poznań University of Medical Sciences, Grunwaldzka 6 Street, 61-702 Poznań, Poland.
出版信息
Oxid Med Cell Longev. 2014;2014:987303. doi: 10.1155/2014/987303. Epub 2014 May 5.
UNLABELLED
The relationship between hyperglycemia and oxidative stress in diabetes is well known, but the influence of metabolic disturbances recognized as prediabetes, in elderly patients especially, awaits for an explanation.
METHODS
52 elderly persons (65 years old and older) with no acute or severe chronic disorders were assessed: waist circumference (WC), body mass index (BMI), percentage of body fat (FAT), and arterial blood pressure. During an oral glucose tolerance test (OGTT) fasting (0') and 120-minute (120') glycemia and insulinemia were determined, and type 2 diabetics (n = 6) were excluded. Subjects were tested for glycated hemoglobin HbA1c, plasma lipids, total antioxidant status (TAS), thiobarbituric acid-reacting substances (TBARS), and activity of erythrocyte superoxide dismutase (SOD-1). According to OGTT results, patients were classified as normoglycemics, (NGT, n = 18) and prediabetics, (PRE, n = 28).
RESULTS
Both groups did not differ with their lipids, FAT, and TBARS. PRE group had higher WC (P < 0.002) and BMI (P < 0.002). Lower SOD-1 activity (P < 0.04) and TAS status (P < 0.04) were found in PRE versus NGT group.
SIGNIFICANCE
In elderly prediabetics, SOD-1 and TAS seem to reflect the first symptoms of oxidative stress, while TBARS are later biomarkers of oxidative stress.
未标注
糖尿病中高血糖与氧化应激之间的关系已为人熟知，但代谢紊乱（尤其是在老年患者中被视为糖尿病前期）的影响尚待解释。
方法
对52名无急性或严重慢性疾病的老年人（65岁及以上）进行评估：测量腰围（WC）、体重指数（BMI）、体脂百分比（FAT）和动脉血压。在口服葡萄糖耐量试验（OGTT）期间，测定空腹（0'）和120分钟（120'）时的血糖和胰岛素水平，并排除2型糖尿病患者（n = 6）。对受试者进行糖化血红蛋白HbA1c、血脂、总抗氧化状态（TAS）、硫代巴比妥酸反应物质（TBARS）以及红细胞超氧化物歧化酶（SOD-1）活性的检测。根据OGTT结果，将患者分为血糖正常者（NGT，n = 18）和糖尿病前期患者（PRE，n = 28）。
结果
两组在血脂、FAT和TBARS方面无差异。PRE组的WC（P < 0.002）和BMI（P < 0.002）较高。与NGT组相比，PRE组的SOD-1活性（P < 0.04）和TAS状态（P < 0.04）较低。
意义
在老年糖尿病前期患者中，SOD-1和TAS似乎反映了氧化应激的最初症状，而TBARS是氧化应激后期的生物标志物。
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