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[对流行性腮腺炎疫苗免疫儿童浆液性脑膜炎的病毒学描述]

[A virological description of serous meningitis in children immunized with vaccine against epidemic parotitis].

作者信息

Goleva O V, Kharit S M, Cherniaeva T V, Aksenov O A, Davidkin I, Kolyshkin V M

出版信息

Vopr Virusol. 2004 Sep-Oct;49(5):28-32.

Abstract

The morbidity structure was analyzed in children vaccinated against epidemic parotitis in 1993-2002. Eight children (4 with serous meningitis and 4 with lesions of the salivary glands) underwent virologic and immunologic examinations. The molecular typing of the SH-gene fragment of the parotitis virus showed the process in 7 cases to be provoked by the vaccination strain. Presumedly, progressing vaccine-associated meningitis inhibits antibody formation. The total incidence of vaccine-associated meningitis was shown, according to Saint Petersburg data, to be not high, which testifies to a low reactogenicity of the Russian vaccine strain.

摘要

对1993年至2002年接种流行性腮腺炎疫苗的儿童的发病结构进行了分析。8名儿童(4名患浆液性脑膜炎,4名有唾液腺病变)接受了病毒学和免疫学检查。腮腺炎病毒SH基因片段的分子分型显示,7例病情由疫苗株引发。据推测,进行性疫苗相关脑膜炎会抑制抗体形成。根据圣彼得堡的数据,疫苗相关脑膜炎的总发病率不高,这证明俄罗斯疫苗株的反应原性较低。

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