Glisson John R, Hofacre Charles L, Mathis Greg F
Department of Avian Medicine, The University of Georgia, Athens, GA 30602, USA.
Avian Dis. 2004 Sep;48(3):658-62. doi: 10.1637/7166.
The purpose of the present study was to compare the ability of enrofloxacin, oxytetracycline, and sulfadimethoxine to reduce morbidity and mortality caused by Escherichia coli (colibacillosis) in broiler chickens. The chickens were raised in 80 pens (20 birds per pen) with 20 pens representing each treatment group under simulated commercial conditions that produced a colibacillosis challenge scenario. Each group of 20 randomized pens (replicates) was given one of four water treatments. Chickens that received enrofloxacin had significantly less mortality (P < 0.01), lower average gross pathology (colibacillosis) scores (P < 0.01), and better feed-conversion ratios (P < 0.05) than did chickens that received either oxytetracycline or no medication. Chickens that received enrofloxacin had significantly less mortality and lower pathology scores than those that received sulfadimethoxine and numerically lower feed conversion than the sulfadimethoxine group. Results from the present study show that enrofloxacin is superior to oxytetracycline and sulfadimethoxine for the control of morbidity and mortality caused by E. coli in broiler chickens. Our findings will help veterinarians choose and prescribe the most efficacious antimicrobial when treating colibacillosis.
本研究的目的是比较恩诺沙星、土霉素和磺胺二甲氧嘧啶降低肉鸡因大肠杆菌感染（大肠杆菌病）所致发病率和死亡率的能力。在模拟商业条件下营造大肠杆菌病挑战场景，将鸡饲养在80个鸡舍中（每个鸡舍20只鸡），每个处理组有20个鸡舍。对每组20个随机鸡舍（重复样本）进行四种饮水处理之一。与接受土霉素或未用药的鸡相比，接受恩诺沙星的鸡死亡率显著更低（P < 0.01），平均大体病理学（大肠杆菌病）评分更低（P < 0.01），饲料转化率更高（P < 0.05）。与接受磺胺二甲氧嘧啶的鸡相比，接受恩诺沙星的鸡死亡率显著更低，病理学评分更低，饲料转化率在数值上低于磺胺二甲氧嘧啶组。本研究结果表明，在控制肉鸡大肠杆菌感染所致发病率和死亡率方面，恩诺沙星优于土霉素和磺胺二甲氧嘧啶。我们的研究结果将有助于兽医在治疗大肠杆菌病时选择和开具最有效的抗菌药物。
