MK-801 upregulates the expression of d-amino acid oxidase mRNA in rat brain.
作者信息
Yoshikawa Masanobu, Oka Tetsuo, Kawaguchi Mitsuru, Hashimoto Atsushi
机构信息
Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, 259-1143, Japan.
出版信息
Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):141-4. doi: 10.1016/j.molbrainres.2004.08.017.
Abstract
We have evaluated the effect of the systemic administration of MK-801 (0.4 mg/kg) on the gene expression of D-amino acid oxidase (DAO) in several brain areas of the rat. The levels of DAO mRNA in all the brain areas significantly increased and peaked at 4 h after the administration. The present results suggest that there is a link between the expression of DAO mRNA and the N-methyl-D-aspartate (NMDA) receptor activity.
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