• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

MK-801 upregulates the expression of d-amino acid oxidase mRNA in rat brain.

作者信息

Yoshikawa Masanobu, Oka Tetsuo, Kawaguchi Mitsuru, Hashimoto Atsushi

机构信息

Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa, 259-1143, Japan.

出版信息

Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):141-4. doi: 10.1016/j.molbrainres.2004.08.017.

DOI:10.1016/j.molbrainres.2004.08.017
PMID:15530664
Abstract

We have evaluated the effect of the systemic administration of MK-801 (0.4 mg/kg) on the gene expression of D-amino acid oxidase (DAO) in several brain areas of the rat. The levels of DAO mRNA in all the brain areas significantly increased and peaked at 4 h after the administration. The present results suggest that there is a link between the expression of DAO mRNA and the N-methyl-D-aspartate (NMDA) receptor activity.

摘要

相似文献

1
MK-801 upregulates the expression of d-amino acid oxidase mRNA in rat brain.
Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):141-4. doi: 10.1016/j.molbrainres.2004.08.017.
2
Effects of MK-801 on the expression of serine racemase and d-amino acid oxidase mRNAs and on the D-serine levels in rat brain.MK-801对大鼠脑内丝氨酸消旋酶和D-氨基酸氧化酶mRNA表达及D-丝氨酸水平的影响。
Eur J Pharmacol. 2007 Jan 19;555(1):17-22. doi: 10.1016/j.ejphar.2006.09.062. Epub 2006 Oct 10.
3
Distribution and MK-801-induced expression of serine racemase mRNA in rat brain by real-time quantitative PCR.通过实时定量PCR检测大鼠脑中丝氨酸消旋酶mRNA的分布及MK-801诱导的表达。
Brain Res Mol Brain Res. 2004 Sep 10;128(1):90-4. doi: 10.1016/j.molbrainres.2004.06.015.
4
Failure of MK-801 to suppress D1 receptor-mediated induction of locomotor activity and striatal preprotachykinin mRNA expression in the dopamine-depleted rat.MK-801未能抑制多巴胺耗竭大鼠中D1受体介导的运动活性诱导及纹状体前速激肽原mRNA表达。
Neuroscience. 2006;137(2):505-17. doi: 10.1016/j.neuroscience.2005.09.024. Epub 2005 Nov 14.
5
Acute treatment with morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.吗啡急性处理可增强大鼠脑中丝氨酸消旋酶和D-氨基酸氧化酶mRNA的表达。
Eur J Pharmacol. 2005 Nov 21;525(1-3):94-7. doi: 10.1016/j.ejphar.2005.09.001. Epub 2005 Oct 27.
6
Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.氯胺酮可增强大鼠大脑中丝氨酸消旋酶和D-氨基酸氧化酶mRNA的表达。
Eur J Pharmacol. 2006 Jul 1;540(1-3):82-6. doi: 10.1016/j.ejphar.2006.04.021. Epub 2006 Apr 28.
7
Counteraction by repetitive daily exposure to static magnetism against sustained blockade of N-methyl-D-aspartate receptor channels in cultured rat hippocampal neurons.通过每日重复暴露于静磁场对培养的大鼠海马神经元中 N-甲基-D-天冬氨酸受体通道持续阻断的对抗作用。
J Neurosci Res. 2005 May 15;80(4):491-500. doi: 10.1002/jnr.20497.
8
MK-801 prevents the increased NMDA-NR1 and NR2B subunits mRNA expression observed in the hippocampus of rats tolerant to diazepam.MK-801可防止在对安定产生耐受性的大鼠海马体中观察到的NMDA-NR1和NR2B亚基mRNA表达增加。
Brain Res. 2004 May 15;1008(1):54-60. doi: 10.1016/j.brainres.2004.01.080.
9
NMDA receptors mediate an early up-regulation of brain-derived neurotrophic factor expression in substantia nigra in a rat model of presymptomatic Parkinson's disease.在症状前帕金森病大鼠模型中，N-甲基-D-天冬氨酸（NMDA）受体介导黑质中脑源性神经营养因子表达的早期上调。
J Neurosci Res. 2009 Aug 1;87(10):2308-18. doi: 10.1002/jnr.22063.
10
[Effects of Ginkgo biloba extract against excitotoxicity induced by NMDA receptors and mechanism thereof].银杏叶提取物抗N-甲基-D-天冬氨酸受体诱导的兴奋毒性作用及其机制
Zhonghua Yi Xue Za Zhi. 2006 Sep 19;86(35):2479-84.

引用本文的文献

1
d-Serine Increases Release of Acetylcholine in Rat Submandibular Glands.D-丝氨酸增加大鼠颌下腺中乙酰胆碱的释放。
Biology (Basel). 2023 Sep 11;12(9):1227. doi: 10.3390/biology12091227.
2
Free d-Amino Acids in Salivary Gland in Rat.大鼠唾液腺中的游离D-氨基酸
Biology (Basel). 2022 Mar 2;11(3):390. doi: 10.3390/biology11030390.
3
d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia.D-氨基酸和 pLG72 在阿尔茨海默病和精神分裂症中的作用。
Int J Mol Sci. 2021 Oct 9;22(20):10917. doi: 10.3390/ijms222010917.
4
Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum.调控小鼠纹状体中天冬氨酸酶和 D-氨基酸氧化酶表达的因素。
Brain Res. 2021 Jan 15;1751:147202. doi: 10.1016/j.brainres.2020.147202. Epub 2020 Nov 7.
5
Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[C]methoxyphenethyl)pyridazin-3(2H)-one, a C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging.4-羟基-6-(3-[C]甲氧基苯乙基)哒嗪-3(2H)-酮的合成及初步评价，一种用于正电子发射断层扫描成像的 C 标记的 D-氨基酸氧化酶（DAAO）抑制剂。
Bioorg Med Chem Lett. 2020 Aug 15;30(16):127326. doi: 10.1016/j.bmcl.2020.127326. Epub 2020 Jun 9.
6
An integrated review on new targets in the treatment of neuropathic pain.关于神经性疼痛治疗新靶点的综合综述。
Korean J Physiol Pharmacol. 2019 Jan;23(1):1-20. doi: 10.4196/kjpp.2019.23.1.1. Epub 2018 Dec 26.
7
D-amino acid oxidase controls motoneuron degeneration through D-serine.D-氨基酸氧化酶通过 D-丝氨酸控制运动神经元变性。
Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):627-32. doi: 10.1073/pnas.1114639109. Epub 2011 Dec 27.
8
The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.D-氨基酸氧化酶的神经生物学及其在精神分裂症中的作用。
Mol Psychiatry. 2010 Feb;15(2):122-37. doi: 10.1038/mp.2009.99. Epub 2009 Sep 29.
9
Expression of kinase interacting with stathmin (KIS, UHMK1) in human brain and lymphoblasts: Effects of schizophrenia and genotype.激酶相互作用的丝氨酸/苏氨酸蛋白激酶 1（KIS，UHMK1）在人脑和淋巴母细胞中的表达：精神分裂症和基因型的影响。
Brain Res. 2009 Dec 8;1301:197-206. doi: 10.1016/j.brainres.2009.08.090. Epub 2009 Sep 9.
10
d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia.人脑中的D-氨基酸氧化酶和丝氨酸消旋酶：精神分裂症中的正常分布及表达改变
Eur J Neurosci. 2007 Sep;26(6):1657-69. doi: 10.1111/j.1460-9568.2007.05769.x.