氯胺酮可增强大鼠大脑中丝氨酸消旋酶和D-氨基酸氧化酶mRNA的表达。
Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.
作者信息
Takeyama Kazuhide, Yoshikawa Masanobu, Oka Tetsuo, Kawaguchi Mitsuru, Suzuki Toshiyasu, Hashimoto Atsushi
机构信息
Department of Anesthesiology, Tokai University School of Medicine, Isehara, Kanagawa, 259-1143, Japan.
出版信息
Eur J Pharmacol. 2006 Jul 1;540(1-3):82-6. doi: 10.1016/j.ejphar.2006.04.021. Epub 2006 Apr 28.
We have evaluated the effects of the acute administration of noncompetitive N-methyl-D-aspartate receptor antagonist, ketamine, on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The ketamine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. These findings suggest that there is a relationship between the gene expression of the d-serine-related enzymes and the blockade of the N-methyl-D-aspartate receptors.
我们评估了急性给予非竞争性N-甲基-D-天冬氨酸受体拮抗剂氯胺酮对大鼠多个脑区中丝氨酸消旋酶和D-氨基酸氧化酶mRNA表达的影响。给予氯胺酮后，所有脑区中丝氨酸消旋酶和D-氨基酸氧化酶mRNA水平均出现剂量依赖性和短暂性升高。这些发现表明，d-丝氨酸相关酶的基因表达与N-甲基-D-天冬氨酸受体的阻断之间存在关联。
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