七价肺炎球菌结合疫苗（PncCRM）在芬兰中耳炎疫苗试验中诱导产生的唾液抗体。

Salivary antibodies induced by the seven-valent PncCRM conjugate vaccine in the Finnish Otitis Media Vaccine Trial.

作者信息

Nurkka Anu, Lahdenkari Mika, Palmu Arto, Käyhty Helena

机构信息

Department of Vaccines, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland.

出版信息

Vaccine. 2004 Dec 2;23(3):298-304. doi: 10.1016/j.vaccine.2004.06.009.

DOI:10.1016/j.vaccine.2004.06.009

PMID:15530671

Abstract

We studied salivary antibodies induced by a seven-valent pneumococcal conjugate vaccine (PncCRM). Healthy Finnish children (n=115), a subcohort of the Finnish Otitis Media (FinOM) Vaccine Trial, were immunised either with the PncCRM or a control vaccine (hepatitis B) at the age of 2, 4, 6, and 12 months. Salivary IgG, IgA, IgA1, IgA2 and sIg for serotypes 6B, 14, 19F, and 23F were measured at 7 and 13 months of age, and IgG and IgA also at 4-5 years of age. The PncCRM could induce both salivary anti-Pnc polysaccharide IgG and IgA. However, by the age of 4-5 years IgA concentrations had increased in both groups and were similar. The increases in IgA concentrations were mostly of IgA1 subclass. The difference between the PncCRM and the control group was more notable for serotypes 6B, 14 and 23F than for serotype 19F. We could not find evidence for the development of mucosal immunologic memory after vaccination with the PncCRM.

摘要

我们研究了七价肺炎球菌结合疫苗（PncCRM）诱导产生的唾液抗体。芬兰中耳炎（FinOM）疫苗试验的一个亚组中的健康芬兰儿童（n = 115）在2、4、6和12月龄时分别接种PncCRM或对照疫苗（乙肝疫苗）。在7和13月龄时检测6B、14、19F和23F血清型的唾液IgG、IgA、IgA1、IgA2和分泌型IgA（sIg），在4至5岁时检测IgG和IgA。PncCRM可诱导唾液中抗肺炎球菌多糖IgG和IgA产生。然而，到4至5岁时，两组的IgA浓度均升高且相似。IgA浓度的升高主要是IgA1亚类。PncCRM组和对照组之间在6B、14和23F血清型上的差异比19F血清型更显著。我们未发现接种PncCRM后黏膜免疫记忆形成的证据。