Ishikawa Takatoshi, Vucenik Ivana, Shamsuddin Abulkalam, Niculescu Florin, Burnett Joseph W
Department of Dermatology, University of Maryland, Baltimore, MD, USA.
Toxicon. 2004 Dec 15;44(8):895-9. doi: 10.1016/j.toxicon.2004.08.017.
Chrysaora quinquecirrha (sea nettle) nematocyst venom is lethal to rainbow killifish (Adina xenica) when injected intraperitoneally or topically applied to the exposed brain or denuded epithelium. The lethal activity is thermostable requiring 100 degrees C heat for inactivation. This paper reports here for the first time that the venom also activates the complement system with the subsequent formation of the C5b-9 terminal complement complex. The events are associated with both a strong chemoattractant release and the tissue damage. These are also, at least in part, responsible for the pathogenesis of some clinical signs and symptoms associated to the jellyfish stings.
当腹腔注射或局部应用于暴露的大脑或剥脱的上皮时，金色海刺水母（Chrysaora quinquecirrha）的刺丝囊毒液对虹鳉（Adina xenica）具有致死性。这种致死活性具有热稳定性，需要100摄氏度加热才能使其失活。本文首次报道该毒液还能激活补体系统，并随后形成C5b - 9末端补体复合物。这些事件与强烈的趋化因子释放和组织损伤有关。它们至少部分地导致了与水母蜇伤相关的一些临床体征和症状的发病机制。
