Massucci Jaime L, Kline Anthony E, Ma Xiecheng, Zafonte Ross D, Dixon C Edward
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Neurosci Lett. 2004 Nov 30;372(1-2):127-31. doi: 10.1016/j.neulet.2004.09.026.
Several studies have demonstrated alterations in the dopamine (DA) system after traumatic brain injury (TBI). The present study investigated the temporal changes in DA tissue levels and metabolism at 1-h or 1, 7, 14, and 28 days after cortical impact or sham injury in rats. DA and DOPAC levels were measured by HPLC in the frontal cortex (FC) and striatum. DA levels were significantly increased at 1h in the contralateral FC and at 1 day in the ipsilateral FC versus respective sham groups. DA and DOPAC levels were significantly increased bilaterally at 1h in the striatum versus sham. These data indicate that TBI induces an early increase in DA and DOPAC, which returns to sham levels over time.
多项研究表明，创伤性脑损伤（TBI）后多巴胺（DA）系统会发生改变。本研究调查了大鼠在皮质撞击或假伤后1小时、1天、7天、14天和28天DA组织水平和代谢的时间变化。通过高效液相色谱法（HPLC）测量额叶皮质（FC）和纹状体中的DA和3,4-二羟基苯乙酸（DOPAC）水平。与各自的假手术组相比，对侧FC在1小时时DA水平显著升高，同侧FC在1天时DA水平显著升高。与假手术组相比，纹状体在1小时时双侧DA和DOPAC水平显著升高。这些数据表明，TBI会导致DA和DOPAC早期升高，随着时间推移会恢复到假手术水平。
