Telenti A, Furrer Hj
Institut de Microbiologie, Centre Hospitalier Universtaire Vaudois, Lausanne.
Ther Umsch. 2004 Oct;61(10):613-8. doi: 10.1024/0040-5930.61.10.613.
Host genetic factors determine the individual natural course of HIV infection and influence the response to therapy and the occurrence of adverse events to treatment. Variants of multiple genes are associated with faster but also slower development of severe immunodeficiency. However, only very rarely the variant of one single gene explains a specific clinical phenotype. But multiple genetic marker form a complex trait, which is difficult to analyse biostatistically. Research in this rapidly evolving field asks for structures in which hypotheses can be generated and evaluated and which combine basic and diagnostic and therapeutic research. The large amount of prospective information on HIV disease natural history and treatment response of the Swiss HIV Cohort Study will make of the Genetics project an excellent test-setting for some of the immediate difficulties in this research field: validation of new markers and modelling of complex traits.
宿主遗传因素决定了个体感染HIV的自然病程，并影响对治疗的反应以及治疗不良事件的发生。多个基因的变异与严重免疫缺陷的快速发展以及缓慢发展都有关联。然而，只有极少数情况下单个基因的变异能解释特定的临床表型。但多个遗传标记构成一个复杂性状，难以用生物统计学方法进行分析。在这个快速发展的领域进行研究需要这样的结构，即能够提出并评估假设，且能将基础研究与诊断和治疗研究相结合。瑞士HIV队列研究中关于HIV疾病自然史和治疗反应的大量前瞻性信息，将使遗传学项目成为解决该研究领域一些紧迫难题的理想测试平台：新标记的验证和复杂性状的建模。
