Anti Marcello, Lippi Maria Enrichetta, Santarelli Luca, Gabrielli Maurizio, Gasbarrini Antonio, Gasbarrini Giovanni
Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Hepatogastroenterology. 2004 Nov-Dec;51(60):1856-9.
BACKGROUND/AIMS: Functional dyspepsia is a major problem in terms of prevalence and drug-therapy expenditures. In dyspeptic patients the symptoms are frequently caused by delayed gastric emptying. Conventional treatment is often inefficient. Mineral-water supplementation is prescribed for the treatment of this condition, but there is no concrete proof of its actual efficacy. The aim of this study was to evaluate the effect of supplementation with mineral waters with high mineral salt contents (Acqua Tettuccio, Acqua Regina, Montecatini Terme) on gastric emptying of solids and symptoms in patients with functional dyspepsia.
Eight patients with functional dyspepsia and two healthy (non-dyspeptic) controls were placed on high-mineral-content water supplementation (500 cc/day) for eight days. Before and after completion of the supplementation treatment, patient symptoms were scored and the 13C-octanoic-acid breath test was administered to assess gastric emptying.
After the treatment, the dyspeptic subjects presented clear decreases in parameters of gastric emptying (half time and lag time) as well as an improvement in symptom scores.
Health spa treatments based on consumption of waters with a high content of mineral salts seem to be capable of improving gastric emptying of solids in dyspeptics. Longer and longitudinal studies are needed to verify the persistence of this effect.
背景/目的:功能性消化不良在患病率和药物治疗费用方面都是一个主要问题。在消化不良患者中,症状通常由胃排空延迟引起。传统治疗往往效果不佳。虽有采用补充矿泉水治疗这种情况的医嘱,但尚无其实际疗效的确切证据。本研究的目的是评估补充高矿盐含量的矿泉水(泰图乔矿泉水、女王矿泉水、蒙特卡蒂尼泰尔梅矿泉水)对功能性消化不良患者固体食物胃排空及症状的影响。
8例功能性消化不良患者和2例健康(无消化不良)对照者接受高矿盐含量水补充(500毫升/天),为期8天。在补充治疗前后,对患者症状进行评分,并进行13C - 辛酸呼气试验以评估胃排空情况。
治疗后,消化不良受试者的胃排空参数(半衰期和延迟时间)明显降低,症状评分也有所改善。
基于饮用高矿盐含量水的温泉疗法似乎能够改善消化不良患者的固体食物胃排空。需要进行更长时间的纵向研究来验证这种效果的持续性。