Takahashi Yoshihisa, Fukushima Jun-ichi, Fukusato Toshio, Shiga Junji
Department of Pathology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, Japan.
Pathol Int. 2004 Nov;54(11):866-71. doi: 10.1111/j.1440-1827.2004.01771.x.
We report a case of sarcomatoid carcinoma with components of small cell carcinoma and undifferentiated carcinoma of the gallbladder. An 84-year-old woman was admitted to our university hospital with right upper abdominal pain and back pain. Clinical diagnosis of a gallbladder tumor was made based on the findings of abdominal ultrasonography, computed tomography and endoscopic retrograde cholangiopancreatography, and a cholecystectomy was carried out. On gross examination a pedunculated polypoid tumor protruded into the lumen of the gallbladder. Histologically the tumor was composed of carcinomatous and sarcomatous components; the carcinomatous component consisted mainly of small cell carcinoma and undifferentiated carcinoma. In general, the carcinomatous component of sarcomatoid carcinoma of the gallbladder consists of adenocarcinoma, and there have only been two previously reported cases in which the carcinomatous component consisted of small cell carcinoma or undifferentiated carcinoma. Because the patient's prognosis may be influenced by the peculiar carcinomatous component in such cases, it is important to accumulate case reports that clarify their clinicopathological features.
我们报告一例具有小细胞癌和未分化癌成分的胆囊肉瘤样癌。一名84岁女性因右上腹疼痛和背痛入住我校医院。根据腹部超声、计算机断层扫描和内镜逆行胰胆管造影的检查结果作出胆囊肿瘤的临床诊断，并进行了胆囊切除术。大体检查可见一个有蒂的息肉样肿瘤突入胆囊腔。组织学上，肿瘤由癌性和肉瘤性成分组成；癌性成分主要由小细胞癌和未分化癌组成。一般来说，胆囊肉瘤样癌的癌性成分由腺癌组成，此前仅有两例报道其癌性成分由小细胞癌或未分化癌组成。由于在此类病例中患者的预后可能受特殊癌性成分的影响，积累阐明其临床病理特征的病例报告很重要。
