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具有软骨分化和神经内分泌癌特征的癌肉瘤:一种罕见的三时相肿瘤,源自胆囊腔内乳头状肿瘤。

Carcinosarcoma with chondroid differentiation and neuroendocrine carcinoma: unusual triphasic tumour arising from intracholecystic papillary neoplasm of the gall bladder.

机构信息

Pathology, The University of Alabama at Birmingham Hospital, Birmingham, Alabama, USA

Pathology, The University of Alabama at Birmingham Hospital, Birmingham, Alabama, USA.

出版信息

BMJ Case Rep. 2022 Jul 20;15(7):e245555. doi: 10.1136/bcr-2021-245555.

Abstract

Herein, we report a man in his 70s with gallbladder mass. Microscopically, the tumour demonstrated moderately differentiated adenocarcinoma, sarcoma with focal chondroid differentiation and high-grade neuroendocrine tumour component arising in an intracholecystic papillary neoplasm. The patient did not receive adjuvant chemotherapy in the setting of complete surgical resection. Patient presented with extensive metastasis after 47 months and died 3 months later. Due to the low incidence and poor prognosis of this tumour, it is essential to gather all the individual experience-based information. To our knowledge, this is the first reported case of carcinosarcoma arising from intracholecystic papillary-tubular neoplasm.

摘要

在此,我们报告一例 70 多岁男性的胆囊肿块。显微镜下,肿瘤表现为中等分化腺癌、肉瘤伴局灶性软骨分化和高级神经内分泌肿瘤成分,发生于胆囊内乳头状肿瘤。患者在完全手术切除的情况下未接受辅助化疗。47 个月后患者出现广泛转移,3 个月后死亡。由于这种肿瘤的发病率低且预后差,因此必须收集所有基于个体经验的信息。据我们所知,这是首例报道的发生于胆囊内乳头状-管状肿瘤的癌肉瘤。

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Carcinosarcoma and carcinoma of the gallbladder.胆囊癌肉瘤与胆囊癌
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本文引用的文献

1
The Landmark Series: Gallbladder Cancer.地标系列:胆囊癌。
Ann Surg Oncol. 2020 Aug;27(8):2846-2858. doi: 10.1245/s10434-020-08654-9. Epub 2020 May 30.
2
Treatment of advanced gallbladder cancer: A SEER-based study.晚期胆囊癌的治疗:基于 SEER 的研究。
Cancer Med. 2020 Jan;9(1):141-150. doi: 10.1002/cam4.2679. Epub 2019 Nov 13.
6
A rare case report of gallbladder carcinosarcoma.胆囊癌肉瘤的一例罕见病例报告。
J Surg Case Rep. 2018 Jul 19;2018(7):rjy167. doi: 10.1093/jscr/rjy167. eCollection 2018 Jul.

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