Kasilima Y S, Wango E O, Kigondu C S, Mutayoba B M, Nyindo M
Department of Animal Physiology, Reproductive Biology Unit, University of Nairobi, P.O. Box 30197, Nairobi, Kenya.
Acta Trop. 2004 Nov-Dec;92(3):165-72. doi: 10.1016/j.actatropica.2004.06.004.
The effects of Schistosoma mansoni (S. mansoni) infection on plasma levels of bioactive luteinising hormone (LH) and testosterone in the New Zealand rabbit model were studied. S. mansoni infection significantly decreased the pulse frequency (P < 0.05), amplitude (P < 0.05), area under LH curve (P < 0.05) and mean plasma LH concentrations (P < 0.05) on days 42 and 70 post-infection, as compared to values for day 14 pre-infection. Areas under the response curves for plasma testosterone levels decreased significantly (P < 0.05) on days 42 and 70 post-infection in infected animals compared to day 14 pre-infection. In the praziquantel-treated group, the levels of LH and testosterone remained unchanged throughout the experimental period. The pulsatile secretion of LH was completely inhibited in S. mansoni-infected animals 70 days post-infection. These results suggest that the effects on reproductive gonadal hormones caused by S. mansoni in the rabbit model may partly be induced by alteration in pituitary synthesis or release of LH.
研究了曼氏血吸虫（S. mansoni）感染对新西兰兔模型血浆中生物活性促黄体生成素（LH）和睾酮水平的影响。与感染前第14天的值相比，曼氏血吸虫感染在感染后第42天和第70天显著降低了脉冲频率（P < 0.05）、幅度（P < 0.05）、LH曲线下面积（P < 0.05）和平均血浆LH浓度（P < 0.05）。与感染前第14天相比，感染动物在感染后第42天和第70天血浆睾酮水平的反应曲线下面积显著降低（P < 0.05）。在吡喹酮治疗组中，LH和睾酮水平在整个实验期间保持不变。感染后70天，曼氏血吸虫感染动物的LH脉冲分泌完全受到抑制。这些结果表明，曼氏血吸虫在兔模型中对生殖性腺激素的影响可能部分是由垂体合成或LH释放的改变所诱导的。
