Lansoud-Soukate J, Leonardelli J, Torpier G, Croix D, Capron A
Centre International de Recherches Médicales de Franceville, Gabon.
Pathol Biol (Paris). 1991 Sep;39(7):681-5.
In tropical and subtropical areas, schistosomiasis may cause anatomic anomalies of the genital organs responsible for permanent or reversible infertility. Furthermore, it has been suggested that this parasitic infection may have adverse consequences on the endocrine system. To specify the effects of schistosomiasis on endocrine function, production of pituitary gonadotropins and testosterone in rats and hamsters experimentally infected with Schistosoma mansoni was studied. Prior to infection, hormone levels were within the normal range for our laboratory in all animals studied. Hormone levels (FSH, LH and testosterone) fell significantly in all experimentally infected animals, as compared with uninfected controls. These data suggest that the inhibitory effect (documented by the fall in all the hormone parameters studied) of Schistosoma mansoni on gonadal function is due to an action at the hypothalamic or pituitary level. The potential role of parasite ecdysteroids in the mechanism of action of schistosomes deserves to be studied.
在热带和亚热带地区，血吸虫病可能导致生殖器官的解剖学异常，从而引起永久性或可逆性不孕。此外，有人提出这种寄生虫感染可能对内分泌系统产生不良影响。为明确血吸虫病对内分泌功能的影响，我们研究了实验感染曼氏血吸虫的大鼠和仓鼠垂体促性腺激素及睾酮的产生情况。在感染前，所有研究动物的激素水平均在我们实验室的正常范围内。与未感染的对照组相比，所有实验感染动物的激素水平（促卵泡激素、促黄体生成素和睾酮）均显著下降。这些数据表明，曼氏血吸虫对性腺功能的抑制作用（通过所研究的所有激素参数下降得以证明）是由于其在下丘脑或垂体水平的作用。寄生虫蜕皮甾体在血吸虫作用机制中的潜在作用值得研究。
