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与长效促性腺激素释放激素（GnRH）方案相比，改良的GnRH拮抗剂方案未能提高临床妊娠率。

A modified gonadotropin-releasing hormone (GnRH) antagonist protocol failed to increase clinical pregnancy rates in comparison with the long GnRH protocol.

作者信息

Loutradis Dimitris, Stefanidis Konstantinos, Drakakis Peter, Milingos Spyridon, Antsaklis Aris, Michalas Stylianos

出版信息

Fertil Steril. 2004 Nov;82(5):1446-8. doi: 10.1016/j.fertnstert.2004.04.051.

DOI:10.1016/j.fertnstert.2004.04.051
PMID:15533377
Abstract

The purpose of this prospective randomized study was to compare stimulation characteristics and IVF outcomes of the standard long GnRH agonist protocol for ovarian stimulation with a modified GnRH antagonist protocol. Starting GnRH antagonist in a flexible protocol according to the size of the leading follicle, with simultaneous augmentation of 75 IU recombinant FSH, failed to increase clinical pregnancy rates.

摘要

这项前瞻性随机研究的目的是比较标准长效促性腺激素释放激素（GnRH）激动剂方案与改良GnRH拮抗剂方案在卵巢刺激方面的刺激特征及体外受精（IVF）结局。根据主导卵泡大小在灵活方案中起始使用GnRH拮抗剂，同时增加75国际单位重组促卵泡生成素（FSH），未能提高临床妊娠率。

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