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对于接受体外受精控制性卵巢刺激的多囊卵巢综合征患者，首选的促性腺激素释放激素类似物是什么？

What is the preferred GnRH analogue for polycystic ovary syndrome patients undergoing controlled ovarian hyperstimulation for in vitro fertilization?

作者信息

Orvieto Raoul, Meltcer Simion, Homburg Roy, Nahum Ravit, Rabinson Jacob, Ashkenazi Jacob

机构信息

Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.

出版信息

Fertil Steril. 2009 Apr;91(4 Suppl):1466-8. doi: 10.1016/j.fertnstert.2008.07.1711. Epub 2008 Sep 6.

DOI:10.1016/j.fertnstert.2008.07.1711
PMID:18774558
Abstract

In an attempt to evaluate the influence of the GnRH analogue used during controlled ovarian hyperstimulation (COH) on the outcome of IVF cycles of polycystic ovary syndrome (PCOS) patients, we studied 152 IVF cycles. The PCOS patients undergoing COH using the GnRH agonist protocol (n = 50) showed a significantly higher pregnancy rate (36% vs. 19.6%, respectively), compared with the GnRH antagonist protocol (n = 102).

摘要

为了评估在控制性卵巢过度刺激（COH）过程中使用的促性腺激素释放激素（GnRH）类似物对多囊卵巢综合征（PCOS）患者体外受精（IVF）周期结局的影响，我们研究了152个IVF周期。与使用GnRH拮抗剂方案（n = 102）的患者相比，采用GnRH激动剂方案进行COH的PCOS患者（n = 50）的妊娠率显著更高（分别为36%和19.6%）。

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