Kishi K, Nakamura K, Yoshimori M, Tajiri H, Ozaki H, Kinoshita T, Kosuge T, Hayakawa M
Division of Clinical Pathology, Saitama Cancer Center Hospital, Japan.
Pancreas. 1992;7(2):177-82. doi: 10.1097/00006676-199203000-00008.
Focal acinar cell dysplasia (FACD) was studied in 138 autopsied pancreases by multiple transsection examination and was found in 13 of the pancreases (9.4%). The average number of FACD per pancreas identified in our study was 5.7, ranging from 1 to 20, and the total number was 60. The location of FACD was 22 in head, 18 in body, and 20 in tail of the pancreas. FACD were rare lesions and found in only 41 of 2,819 slides (1.5%). The incidence of FACD seemed to be higher among males than among females, among patients with cancer in other sites than among those with no cancer, among diabetics than among nondiabetics, among heavy smokers than among nonsmokers, and among alcohol abusers than among abstainers. The males and heavy smokers had significantly more nodules of FACD per pancreas than females and nonsmokers. Simple and atypical hyperplasia of pancreatic ducts were found in 119 (86.2%) and 18 (13.0%), respectively. All pancreases with FACD had simple ductal hyperplasia. FACD and atypical ductal hyperplasia coexisted in one patient who had a history of heavy smoking, and this patient had the most nodules of FACD per pancreas among patients with FACD. No FACD was observed in pancreases without ductal hyperplasia. These findings suggested heavy cigarette smoking was one of the possible causes of FACD and ductal hyperplasia of pancreas.
通过多次横切检查，对138例胰腺尸检样本进行了局灶性腺泡细胞发育异常（FACD）研究，发现13例胰腺存在该病变（9.4%）。在我们的研究中，每个胰腺中识别出的FACD平均数量为5.7个，范围为1至20个，总数为60个。FACD的位置在胰头有22个，胰体有18个，胰尾有20个。FACD是罕见病变，在2819张切片中仅发现41例（1.5%）。FACD的发病率在男性中似乎高于女性，在有其他部位癌症的患者中高于无癌症患者，在糖尿病患者中高于非糖尿病患者，在重度吸烟者中高于非吸烟者，在酗酒者中高于戒酒者。男性和重度吸烟者每个胰腺的FACD结节明显多于女性和非吸烟者。分别在119例（86.2%）和18例（13.0%）中发现了胰腺导管的单纯性增生和非典型增生。所有存在FACD的胰腺均有导管单纯性增生。一名有重度吸烟史的患者同时存在FACD和导管非典型增生，该患者在患有FACD的患者中每个胰腺的FACD结节最多。在无导管增生的胰腺中未观察到FACD。这些发现表明，重度吸烟是FACD和胰腺导管增生的可能原因之一。
