Kozuka S, Sassa R, Taki T, Masamoto K, Nagasawa S, Saga S, Hasegawa K, Takeuchi M
Cancer. 1979 Apr;43(4):1418-28. doi: 10.1002/1097-0142(197904)43:4<1418::aid-cncr2820430431>3.0.co;2-o.
In order to find a relationship between ductal hyperplasia and carcinoma of the pancreas, histological and histochemical examinations were made on pancreatic specimens of 1,174 autopsy patients with special attention to the age incidence of the former. Ductal hyperplasia was divided into 3 types; nonpapillary, papillary, and atypical hyperplasia. All three types of hyperplasia and ductal carcinoma showed a similar tinctorial property in mucous histochemistry. In general, atypical hyperplasia was seen in the pancreas having papillary hyperplasia which was found in the pancreas associated with nonpapillary hyperplasia. All three types of hyperplasia were apparently more frequent in cancerous pancreases than in non-cancerous ones. They were also more common in the head of the pancreas than in the body and tail. Age incidence also suggests a sequential change from nonpapillary hyperplasia through papillary and atypical ones to carcinoma.
为了探寻胰腺导管增生与胰腺癌之间的关系，对1174例尸检患者的胰腺标本进行了组织学和组织化学检查，并特别关注了前者的年龄发病率。导管增生分为3种类型：非乳头状、乳头状和非典型增生。在黏液组织化学中，所有这三种增生类型和导管癌均表现出相似的染色特性。一般来说，非典型增生见于有乳头状增生的胰腺，而乳头状增生见于伴有非乳头状增生的胰腺。这三种增生类型在癌性胰腺中明显比在非癌性胰腺中更为常见。它们在胰头也比在胰体和胰尾更常见。年龄发病率也表明从非乳头状增生经乳头状和非典型增生到癌存在一种序贯变化。
