Altenberg B, Greulich K O
Bioinformatics Group, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.
Genomics. 2004 Dec;84(6):1014-20. doi: 10.1016/j.ygeno.2004.08.010.
Using NIH's public database dbEST for expression of genes and ESTs, genes of the glycolysis pathway have been found to be overexpressed in a set of 24 cancers representing more than 70% of human cancer cases worldwide. Genes can be classified as those that are almost ubiquitously overexpressed, particularly glyceraldehyde-3-phosphate dehydrogenase, enolase 1, and also pyruvate kinase, and those that are overexpressed in less than 50% of the investigated cancers. Cancers can be classified as those with overexpression of the majority of the glycolysis genes, particularly lymph node, prostate, and brain cancer, in which essentially all glycolysis genes are overexpressed, and those with only sporadic overexpression, particularly cancers of the cartilage or bone marrow. This classification may be useful when cancer therapies aimed at the Warburg effect are designed.
利用美国国立卫生研究院（NIH）的公共数据库dbEST来分析基因和EST的表达情况，研究发现糖酵解途径中的基因在一组24种癌症中过度表达，这些癌症占全球人类癌症病例的70%以上。基因可分为两类：一类是几乎普遍过度表达的基因，特别是甘油醛-3-磷酸脱氢酶、烯醇化酶1以及丙酮酸激酶；另一类是在不到50%的被研究癌症中过度表达的基因。癌症也可分为两类：一类是大多数糖酵解基因过度表达的癌症，特别是淋巴结癌、前列腺癌和脑癌，在这些癌症中，基本上所有糖酵解基因都过度表达；另一类是只有零星过度表达的癌症，特别是软骨癌或骨髓癌。在设计针对瓦伯格效应的癌症治疗方法时，这种分类可能会有所帮助。
