Nakayama Tomohiro, Soma Masayoshi, Sato Naoyuki, Haketa Akira, Kosuge Kotoko, Aoi Noriko, Sato Mikano, Izumi Yoichi, Matsumoto Koichi, Kanmatsuse Katsuo, Kokubun Shinichiro
Division of Receptor Biology, Advanced Medical Research Center, Nihon University School of Medicine, Tokyo, Japan.
Am J Hypertens. 2004 Nov;17(11 Pt 1):1045-9. doi: 10.1016/j.amjhyper.2004.07.010.
Lymphotoxin-alpha (LTA), a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The substance LTA mediates a wide variety of inflammatory, immunostimulatory, and antiviral responses. In 2002, LTA was identified as a major risk factor for myocardial infarction (MI) in Japanese individuals, in a large-scale case-control study using 92,788 gene-based single-nucleotide polymorphism (SNP) markers in the whole human genome. Essential hypertension (EH) is thought to be a multifactorial disorder involved in endothelial dysfunction and atherosclerosis. Although hypertension is one of the greatest risk factors for MI, there have been no reports estimating the association between EH and LTA. The aim of the present study was to evaluate the association between EH and the LTA gene.
In the present study, we assessed the association between EH and SNP and haplotypes of the LTA gene in a case-control study of 202 EH patients and 217 age-matched normotensive control subjects.
The overall distribution of genotypes for each SNP did not significantly differ between the two groups. Furthermore, the haplotype analysis revealed no association between the EH and normotensive groups.
Polymorphisms of the LTA gene were not associated with EH. This finding suggests differences in genetic backgrounds between EH and MI.
淋巴毒素-α（LTA）是肿瘤坏死因子家族的成员，是一种由淋巴细胞产生的细胞因子。LTA可介导多种炎症、免疫刺激和抗病毒反应。2002年，在一项使用全人类基因组中92788个基于基因的单核苷酸多态性（SNP）标记的大规模病例对照研究中，LTA被确定为日本人群中心肌梗死（MI）的主要危险因素。原发性高血压（EH）被认为是一种涉及内皮功能障碍和动脉粥样硬化的多因素疾病。虽然高血压是MI的最大危险因素之一，但尚无关于EH与LTA之间关联的报道。本研究的目的是评估EH与LTA基因之间的关联。
在本研究中，我们在一项病例对照研究中评估了202例EH患者和217例年龄匹配的血压正常对照者中EH与LTA基因的SNP及单倍型之间的关联。
两组中每个SNP的基因型总体分布无显著差异。此外，单倍型分析显示EH组与血压正常组之间无关联。
LTA基因多态性与EH无关。这一发现提示EH和MI在遗传背景上存在差异。
