Sanderson Ralph D, Yang Yang, Suva Larry J, Kelly Thomas
Department of Pathology and Arkansas Cancer Research Center, University of Arkansas, for Medical Sciences, Little Rock, AR, USA.
Matrix Biol. 2004 Oct;23(6):341-52. doi: 10.1016/j.matbio.2004.08.004.
This review summarizes a series of studies demonstrating that heparan sulfate proteoglycans act to promote the growth and metastasis of myeloma and breast tumors, two tumors that home to, and grow within, bone. Much of the growth-promoting effect of proteoglycans in these tumors may reside in the shed form of syndecan-1 that acts to favorably condition the tumor microenvironment. Moreover, the interplay between heparan sulfate and the extracellular enzyme heparanase-1 also has important regulatory implications. Recent studies indicate that the activity of heparanase, which likely releases heparin sulfate-bound growth factors and generates highly active heparan sulfate fragments, also promotes growth and metastasis of myeloma and breast tumors. Understanding the role of heparan sulfate and heparanase in the regulation of tumor behavior may lead to new therapeutic approaches for treating cancer.
本综述总结了一系列研究，这些研究表明硫酸乙酰肝素蛋白聚糖可促进骨髓瘤和乳腺肿瘤的生长和转移，这两种肿瘤定位于骨并在骨内生长。蛋白聚糖在这些肿瘤中的促生长作用很大程度上可能在于syndecan-1的脱落形式，它可对肿瘤微环境产生有利影响。此外，硫酸乙酰肝素与细胞外酶乙酰肝素酶-1之间的相互作用也具有重要的调节意义。最近的研究表明，乙酰肝素酶的活性可能释放与硫酸乙酰肝素结合的生长因子并产生高活性的硫酸乙酰肝素片段，这也促进了骨髓瘤和乳腺肿瘤的生长和转移。了解硫酸乙酰肝素和乙酰肝素酶在调节肿瘤行为中的作用可能会带来治疗癌症的新方法。
