Li Zhi-Hong, Yang Shi-Ming
Department of Gastroenterology, Southwest Hospital, The Third Military Medical University, Chongqing, P.R. China.
Ai Zheng. 2005 Sep;24(9):1156-60.
Heparanase is the only mammalian heparan sulfate-degrading enzymes; it could cleave heparan sulfate (HS) which links to heparan sulfate proteoglycans (HSPGs). In this review, the heparanase's structure, function, molecular properties, gene location, nucleotide sequence, its effects on tumor angiogenesis, its expression in normal tissue, tumor tissue and metastatic tissue, and its correlation to tumor metastasis were described; recent progress in searching for novel antitumor drugs through screening for inhibitor of heparanase was summarized.
乙酰肝素酶是唯一的哺乳动物硫酸乙酰肝素降解酶；它能够切割与硫酸乙酰肝素蛋白聚糖（HSPGs）相连的硫酸乙酰肝素（HS）。在这篇综述中，描述了乙酰肝素酶的结构、功能、分子特性、基因定位、核苷酸序列、其对肿瘤血管生成的影响、其在正常组织、肿瘤组织和转移组织中的表达，以及其与肿瘤转移的相关性；总结了通过筛选乙酰肝素酶抑制剂来寻找新型抗肿瘤药物方面的最新进展。
