DNA甲基转移酶基因dDnmt2与果蝇的寿命

DNA methyltransferase gene dDnmt2 and longevity of Drosophila.

作者信息

Lin Meng-Jau, Tang Lin-Ya, Reddy M Narsa, Shen C-K James

机构信息

Institute of Molecular Medicine, National Taiwan University, Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, Republic of China.

出版信息

J Biol Chem. 2005 Jan 14;280(2):861-4. doi: 10.1074/jbc.C400477200. Epub 2004 Nov 8.

DOI:10.1074/jbc.C400477200

PMID:15533947

Abstract

The DNA methylation program of the fruit fly Drosophila melanogaster is carried out by the single DNA methyltransferase gene dDnmt2, the function of which is unknown before. We present evidence that intactness of the gene is required for maintenance of the normal life span of the fruit flies. In contrast, overexpression of dDnmt2 could extend Drosophila life span. The study links the Drosophila DNA methylation program with the small heatshock proteins and longevity/aging and has interesting implication on the eukaryotic DNA methylation programs in general.

摘要

果蝇黑腹果蝇的DNA甲基化程序由单个DNA甲基转移酶基因dDnmt2执行，其功能此前未知。我们提供的证据表明，该基因的完整性是维持果蝇正常寿命所必需的。相比之下，dDnmt2的过表达可以延长果蝇的寿命。这项研究将果蝇的DNA甲基化程序与小热休克蛋白以及寿命/衰老联系起来，总体上对真核生物的DNA甲基化程序具有有趣的启示。