Baudic Sophie, Tzortzis Catherine, Barba Gianfranco Dalla, Traykov Latchezar
INSERM/UPVM U421, Faculté de Médecine, 8 rue du Général Sarrail, 94010 Créteil cedex, France.
J Geriatr Psychiatry Neurol. 2004 Dec;17(4):195-201. doi: 10.1177/0891988704269823.
Several studies have evaluated executive function in depressed patients, and the results vary from significant impairment relative to controls to virtually intact performances. To better comprehend executive impairment in elderly patients with major unipolar depression, the performance of 21 elderly depressed patients was compared with that of 19 elderly normal controls on executive tasks. The relationships between memory deficits and depression severity and between memory deficits and executive dysfunction were also examined. Depressed patients' performance was significantly worse than that of controls on almost all executive tasks. Their score for logical memory was significantly correlated with that for several executive tasks. Executive performance was also correlated with depression severity. Unipolar depressed patients present executive deficits. Memory failure in these patients may reflect impairment in retrieval processes, which in turn depends on executive function. Executive deficits are associated with depression severity. These results may be useful in the differential diagnosis between depression and early Alzheimer's disease.
多项研究评估了抑郁症患者的执行功能，结果从相对于对照组有显著损害到几乎表现完好不等。为了更好地理解老年单相抑郁症患者的执行功能损害情况，对21名老年抑郁症患者和19名老年正常对照者在执行任务方面的表现进行了比较。还研究了记忆缺陷与抑郁严重程度之间以及记忆缺陷与执行功能障碍之间的关系。在几乎所有执行任务中，抑郁症患者的表现都明显比对照组差。他们的逻辑记忆得分与几项执行任务的得分显著相关。执行功能表现也与抑郁严重程度相关。单相抑郁症患者存在执行功能缺陷。这些患者的记忆障碍可能反映了检索过程中的损害，而检索过程又依赖于执行功能。执行功能缺陷与抑郁严重程度相关。这些结果可能有助于抑郁症与早期阿尔茨海默病的鉴别诊断。
