轮班工作、工作压力与晚期胎儿丢失：丹麦国家出生队列研究
Shift work, job stress, and late fetal loss: The National Birth Cohort in Denmark.
作者信息
Zhu Jin Liang, Hjollund Niels Henrik, Andersen Anne-Marie Nybo, Olsen Jørn
机构信息
Danish Epidemiology Science Centre, University of Aarhus, DK-8000 Aarhus, Denmark.
出版信息
J Occup Environ Med. 2004 Nov;46(11):1144-9. doi: 10.1097/01.jom.0000145168.21614.21.
OBJECTIVE
The Danish National Birth Cohort (DNBC) was used to examine whether shift work or job stress correlate with late fetal loss.
METHODS
We identified 33,694 pregnancies of daytime workers and 8,075 pregnancies of shift workers in women recruited to the DNBC between 1998 and 2001. Pregnancy outcomes were obtained by linkages to the national registers. Hazard ratios of fetal loss were calculated by using Cox regressions with left truncation.
RESULTS
Fixed night work was associated with fetal loss (hazard ratio = 1.85, 95% confidence interval = 1.00-3.42). No high risk of fetal loss was seen for other types of shift work. Job stress, as measured in our study, was not associated with fetal loss.
CONCLUSIONS
Our results suggest that fixed night work during pregnancy increases the risk of late fetal loss.
目的
利用丹麦国家出生队列（DNBC）研究轮班工作或工作压力是否与晚期胎儿丢失相关。
方法
我们在1998年至2001年招募到DNBC的女性中，确定了33694例白天工作女性的妊娠和8075例轮班工作女性的妊娠。通过与国家登记处的关联获得妊娠结局。使用左截断的Cox回归计算胎儿丢失的风险比。
结果
固定夜班工作与胎儿丢失相关（风险比=1.85，95%置信区间=1.00-3.42）。其他类型的轮班工作未观察到胎儿丢失的高风险。在我们的研究中测量的工作压力与胎儿丢失无关。
结论
我们的结果表明，孕期固定夜班工作会增加晚期胎儿丢失的风险。
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