Strandberg-Larsen Katrine, Nielsen Naja Rod, Grønbaek Morten, Andersen Per Kragh, Olsen Jørn, Andersen Anne-Marie Nybo
Centre for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Obstet Gynecol. 2008 Mar;111(3):602-9. doi: 10.1097/AOG.0b013e3181661431.
To examine whether the frequency and timing of binge drinking episodes (intake of five or more drinks on one occasion) during the first 16 weeks of pregnancy increase the risk of fetal death.
The study is based upon data from 89,201 women who were enrolled in the Danish National Birth Cohort from 1996 to 2002 and participated in an interview that took place in midpregnancy (n=86,752) or after a fetal loss (n=2,449). In total, 3,714 pregnancies resulted in fetal death. Data were analyzed by means of Cox regression models.
Neither the frequency nor the timing of binge episodes was related to the risk of early (at or before 12 completed weeks) or late (13-21 completed weeks) spontaneous abortion. However, three or more binge episodes showed an adjusted hazard ratio of 1.56 (95% confidence interval 1.01-2.40) for stillbirth (22 or more completed weeks) relative to nonbinge drinkers. Women with an average intake of three or more drinks per week and two or more binge drinking episodes had a hazard ratio of 2.20 (95% confidence interval 1.73-2.80) compared with women with no average intake and no binge drinking.
Binge drinking three or more times during pregnancy is associated with an increased risk of stillbirth, but neither frequency nor timing of binge drinking was associated with an increased risk of spontaneous abortion in clinically recognized pregnancies.
研究孕期前16周内暴饮发作（一次摄入五杯或更多饮品）的频率和时间是否会增加胎儿死亡风险。
本研究基于1996年至2002年纳入丹麦国家出生队列的89,201名女性的数据，这些女性参与了孕中期（n = 86,752）或胎儿丢失后（n = 2,449）的访谈。总共有3,714例妊娠导致胎儿死亡。数据通过Cox回归模型进行分析。
暴饮发作的频率和时间均与早期（妊娠12周及以前）或晚期（妊娠13 - 21周）自然流产风险无关。然而，与非暴饮者相比，三次或更多次暴饮发作的死产（妊娠22周及以后）调整后风险比为1.56（95%置信区间1.01 - 2.40）。平均每周摄入三杯或更多饮品且有两次或更多次暴饮发作的女性与无平均摄入量且无暴饮发作的女性相比，风险比为2.20（95%置信区间1.73 - 2.80）。
孕期暴饮三次或更多次与死产风险增加相关，但在临床确诊的妊娠中，暴饮的频率和时间均与自然流产风险增加无关。
