Oguz K K, Anlar B, Senbil N, Cila A
Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Neuropediatrics. 2004 Oct;35(5):279-82. doi: 10.1055/s-2004-821301.
Magnetic resonance (MR) imaging has an important role in the diagnosis of metachromatic leukodystrophy (MLD). We report diffusion-weighted MR imaging (DWI) findings of four cases of juvenile type MLD. DWI showed restricted diffusion lines with greater areas of increased diffusion in three patients and widespread increased diffusion in one patient. This variability in DWI findings can be related to the histological stage of the disease at the time of imaging, ranging from intracellular metachromatic material accumulation to breakdown of myelin membranes.
磁共振成像（MR）在异染性脑白质营养不良（MLD）的诊断中具有重要作用。我们报告了4例青少年型MLD的扩散加权磁共振成像（DWI）表现。DWI显示3例患者有扩散受限线，扩散增加区域更大，1例患者有广泛的扩散增加。DWI表现的这种变异性可能与成像时疾病的组织学阶段有关，范围从细胞内异染物质积累到髓鞘膜破坏。
