Stayner L T, Dannenberg A L, Thun M, Reeve G, Bloom T F, Boeniger M, Halperin W
National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Scand J Work Environ Health. 1992 Feb;18(1):34-43. doi: 10.5271/sjweh.1610.
A retrospective cohort mortality study with 5529 nitroglycerin, 4989 dinitrotoluene, and 5136 unexposed workers compared the mortality of the exposed groups with that of the United States population and that of the unexposed group with life-table analysis and Poisson regression. Mortality from ischemic heart disease was close to that expected, and mortality from cerebrovascular disease was slightly less than that expected, for the workers with both nitroglycerin and dinitrotoluene exposure and for those with dinitrotoluene exposure only. A significant interaction between age and nitroglycerin exposure was detected in the Poisson regression analyses for ischemic heart disease, particularly for workers actively exposed to nitroglycerin. The rate ratio for the workers under 45 years of age and actively exposed to nitroglycerin was 3.30 (95% confidence interval 129-8.48). This study did not show a chronic effect of nitroglycerin or dinitrotoluene exposure on cardiovascular disease risk. Potential biases related to the company's medical screening program may have limited the ability to detect chronic cardiovascular effects.
一项回顾性队列死亡率研究，涉及5529名接触硝酸甘油的工人、4989名接触二硝基甲苯的工人以及5136名未接触者，通过寿命表分析和泊松回归，比较了接触组与美国人群以及未接触组的死亡率。对于同时接触硝酸甘油和二硝基甲苯的工人以及仅接触二硝基甲苯的工人，缺血性心脏病死亡率接近预期，脑血管疾病死亡率略低于预期。在缺血性心脏病的泊松回归分析中，检测到年龄与硝酸甘油接触之间存在显著交互作用，特别是对于积极接触硝酸甘油的工人。45岁以下且积极接触硝酸甘油的工人的率比为3.30（95%置信区间1.29 - 8.48）。本研究未显示接触硝酸甘油或二硝基甲苯对心血管疾病风险有慢性影响。与公司医疗筛查计划相关的潜在偏倚可能限制了检测慢性心血管影响的能力。
