Galán Amparo, Curós Antonio, Corominas Augusto
Servicio de Bioquímica Clínica, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain.
Med Clin (Barc). 2004 Oct 23;123(14):551-6. doi: 10.1016/s0025-7753(04)74592-3.
Patients with renal insufficiency can have elevations of serum troponin without suspected clinical coronary ischemia. Although cardiovascular disease is the main cause of death in patients with renal failure, the process of elevation of serum troponin is not well known. Troponin T is more frequently elevated than troponin I in these patients which leads to uncertainty in the clinical interpretation of results. There are studies suggesting that troponin elevations are associated with a higher risk and increased mortality. To explain the process leading to troponin increases in this kind of pathology and to confirm its usefulness in the diagnosis, evolution and prognosis it would be necessary to carry out more clinical studies monitoring troponin and studying the stratification of risk.
肾功能不全患者可出现血清肌钙蛋白升高，而无临床可疑的冠状动脉缺血。虽然心血管疾病是肾衰竭患者的主要死因，但血清肌钙蛋白升高的过程尚不清楚。在这些患者中，肌钙蛋白T比肌钙蛋白I更频繁升高，这导致结果的临床解释存在不确定性。有研究表明，肌钙蛋白升高与更高风险和死亡率增加相关。为了解释导致这类病理状态下肌钙蛋白升高的过程，并证实其在诊断、病情演变及预后评估中的作用，有必要开展更多监测肌钙蛋白并研究风险分层的临床研究。
