Plas Daniel T, Visel Axel, Gonzalez Ernesto, She Wei-Chi, Crair Michael C
Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza S-603, Houston, TX 77030, USA.
Vision Res. 2004 Dec;44(28):3357-64. doi: 10.1016/j.visres.2004.09.036.
Development of the retino-collicular pathway has served as an important model system for examining the cellular mechanisms responsible for the establishment of neuronal maps of the sensory periphery. A consensus has emerged that molecular or chemical cues are responsible for the initial establishment of gross topography in this map, and that activity dependent factors sharpen this initial rough topography into precision. However, there is little evidence available concerning the biochemical signaling mechanisms that are responsible for topographic map refinement in the retino-collicular system. Using a combination of anatomical and biochemical techniques in normal and mutant mice, we provide evidence that Ca2+/Calmodulin regulated Adenylate Cyclase 1 (AC1), which is strongly expressed in the superficial layers of the colliculus, is an important downstream signaling agent for activity dependent map refinement in the superior colliculus.
视网膜-丘脑途径的发育已成为研究负责建立感觉外周神经元图谱的细胞机制的重要模型系统。目前已形成一种共识，即分子或化学信号负责该图谱中总体拓扑结构的初步建立，而活动依赖因素则将这种初始的粗略拓扑结构细化为精确结构。然而，关于视网膜-丘脑系统中负责拓扑图谱细化的生化信号机制，几乎没有可用的证据。通过在正常和突变小鼠中结合解剖学和生化技术，我们提供证据表明，在丘脑中表层强烈表达的Ca2+/钙调蛋白调节的腺苷酸环化酶1（AC1）是上丘中活动依赖图谱细化的重要下游信号传导因子。
