Fournel P
Service de Pneumologie, Hôpital Nord, 42055 Saint-Etienne 2.
Rev Pneumol Clin. 2004 Nov;60(5 Pt 2):3S43-7.
The prognosis of locally advanced and non-resectable non-small cell lung cancers (NSCLC) remains poor, despite the therapeutic progress made over the past few years. The best therapeutic strategy is currently the concomitant association of chemotherapy and radiotherapy. Such treatment must be reserved for patients in general state of good health. Oesophagitis is the principle limiting toxicity. The objectives for the years to come are to improve the results and to reduce the toxicity by optimising radiotherapy, using new chemotherapy drugs, and by pinpointing the therapeutic strategy. The sequential association of chemotherapy and radiotherapy still retains its place for the other patients.
尽管在过去几年里取得了治疗进展,但局部晚期和不可切除的非小细胞肺癌(NSCLC)的预后仍然很差。目前最佳的治疗策略是化疗与放疗联合应用。这种治疗必须仅用于一般健康状况良好的患者。食管炎是主要的限制性毒性反应。未来几年的目标是通过优化放疗、使用新的化疗药物以及精准确定治疗策略来提高治疗效果并降低毒性。化疗和放疗序贯联合对其他患者仍有其应用价值。