Isoardo G, Migliaretti G, Ciaramitaro P, Rota E, Poglio F, Tavella A, Paolasso I, Cavallo F, Bergamasco B, Cocito D
Divisione di Neurologia, Ospedale Civile, Via Botallo 4, 14100 Asti, Italy.
Muscle Nerve. 2005 Jan;31(1):52-8. doi: 10.1002/mus.20230.
The distinction between chronic demyelinating polyneuropathies associated with IgM paraproteinemia and anti-myelin-associated glycoprotein (MAG) antibodies (MAG-PN) and chronic inflammatory demyelinating polyneuropathies (CIDPs) relies on the anti-MAG antibodies assay. The aim of the study was to identify clinical and electrophysiological features suggesting a diagnosis of MAG-PN. Fourteen patients with MAG-PN and 35 with CIDP were included, and a discriminant analysis was performed to identify the clinical and electrophysiological features suggestive of MAG-PN. Pure sensory clinical phenotype, low median and ulnar terminal latency index, and absence of M responses in the lower limbs were significantly associated with the diagnosis of MAG-PN, and indicate a moderate to large increase in probability of this diagnosis in patients with chronic dysimmune demyelinating polyneuropathies.
与IgM副蛋白血症和抗髓鞘相关糖蛋白（MAG）抗体相关的慢性脱髓鞘性多发性神经病（MAG-PN）与慢性炎症性脱髓鞘性多发性神经病（CIDP）之间的区别依赖于抗MAG抗体检测。本研究的目的是确定提示MAG-PN诊断的临床和电生理特征。纳入了14例MAG-PN患者和35例CIDP患者，并进行判别分析以确定提示MAG-PN的临床和电生理特征。纯感觉临床表型、低正中神经和尺神经末端潜伏期指数以及下肢无M波反应与MAG-PN诊断显著相关，表明慢性免疫性脱髓鞘性多发性神经病患者诊断为此病的概率有中度到大幅增加。
