Argüelles Salido Enrique, Barrero Candau Rafael, Torrubia Romero Francisco Javier, Cruz Navarro Natalio, Leal Arenas José, Montañés Medina Pedro
Servicio de Urología, Hospital Universitario Virgen del Rocío, Sevilla, España.
Arch Esp Urol. 2004 Sep;57(7):699-705.
Kidney transplantation (KT) is the treatment of choice for patients with end stage renal disease (ESRD). 6% of the patients develop ESRD due to congenital or acquired lower urinary tract anomalies, which sometimes imply the need of an additional surgical procedure to make the patient suitable for transplantation.
We review 6 cases of KT receptors (three of them pediatric) to whom some kind of reconstruction of the lower urinary tract with bowel was performed over the last 10 years.
Most frequent etiologies: neurogenic bladder (3), small and contracted bladder after genitourinary tuberculosis, urethral valves, and transitional cell carcinoma with radical cystoprostatectomy and bilateral nephrectomy. Surgical techniques: Bladder augmentation with colon (3), Bricker's defunctionalized ileal loop (2), and Goodwin 's ileal bladder augmentation; all of them were performed between 8 and 147 months before transplant.
UTI in 2 patients. Recurrent stenosis of the ileal loop in one patient who required endoscopic balloon dilation and stent placement in the stenotic segment with poor results and finally requiring loop reconstruction. Another patient developed stenosis of the ureteroneocystostomy anastomosis and reimplant was performed. All of them had good outcome. One case had a subacute kidney rejection episode with good response to steroids. No graft was lost. Current serum creatinine values are between 0.69 and 2.6.
The use of bowel in patients with pathologic bladders is as safe method to allow these patients to receive a kidney transplant when bladder rehabilitation has not been possible with conservative measures.
肾移植(KT)是终末期肾病(ESRD)患者的首选治疗方法。6%的患者因先天性或后天性下尿路异常而发展为ESRD,这有时意味着需要额外的手术来使患者适合移植。
我们回顾了过去10年中6例接受肾移植的患者(其中3例为儿童),他们均接受了某种肠道重建下尿路的手术。
最常见的病因:神经源性膀胱(3例)、泌尿生殖系结核后膀胱小且挛缩、尿道瓣膜以及行根治性膀胱前列腺切除术和双侧肾切除术后的移行细胞癌。手术技术:结肠扩大膀胱术(3例)、Bricker去功能化回肠袢术(2例)以及Goodwin回肠扩大膀胱术;所有手术均在移植前8至147个月进行。
2例患者发生尿路感染。1例患者回肠袢反复狭窄,需要在内镜下对狭窄段进行球囊扩张和支架置入,但效果不佳,最终需要重建肠袢。另1例患者输尿管膀胱吻合口狭窄,进行了再次植入。所有患者预后良好。1例患者发生亚急性肾排斥反应,对类固醇治疗反应良好。无移植肾丢失。目前血清肌酐值在0.69至2.6之间。
对于膀胱病变患者,当保守措施无法实现膀胱功能康复时,使用肠道进行手术是使这些患者能够接受肾移植的一种安全方法。