Eisman John, Clapham Sharon, Kehoe Linda
Garvan Institute of Medical Research, University of New South Wales, St. Vincent's Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.
J Bone Miner Res. 2004 Dec;19(12):1969-75. doi: 10.1359/JBMR.040905. Epub 2004 Sep 13.
The level of recognition and treatment of osteoporosis is not well characterized in primary care. In data from a large sample of postmenopausal women attending 927 primary care physicians, 29% of women reported one or more fractures after menopause. The great majority (72%) were not on any osteoporosis-specific therapy.
Osteoporosis is often first recognized at the time of a low-trauma fracture. However, by this stage, the risk of subsequent fractures has already risen substantially. Moreover, in many countries, only a small proportion of women, who have already sustained fractures, receive a treatment shown to reduce this increased risk of further fractures.
This project was initiated to examine the prevalence of osteoporotic fractures, risk factors for osteoporosis, and use of antifracture therapy among postmenopausal Australian women. More than 88,000 women from 927 primary care physicians returned over 69,358 surveys. Of these, 57,088 reported the presence of a postmenopausal fracture or risk factors.
Among these randomly selected postmenopausal women, 29% reported having had one or more low-trauma fractures after menopause (44% substantiated in current records). One-third of these women reported multiple fractures. The prevalence of all types of fractures, except rib and ankle, increased with age and low body weight. Those who reported fractures were also more likely to report early menopause, corticosteroid use, and a family history of osteoporosis. Moreover, those with vertebral fractures were more likely to record height loss, kyphosis, and back pain. Physical inactivity, low calcium intake, and smoking had no consistent relationship with any fracture outcome. Of the women who reported a fracture after menopause, only 28% were on any specific therapy for osteoporosis, and 7% were on calcium alone. Of those who had been told they had osteoporosis by a doctor, 40% were receiving specific osteoporosis therapy.
In this large study of postmenopausal Australian women attending primary care physicians, 29% reported at least one low-trauma fracture after menopause. Less than one-third of these women were on specific treatment for osteoporosis, and only 40% were ever told they had osteoporosis. Therefore, osteoporotic fractures are common in postmenopausal Australian women, and few, despite their substantially increased risk of further fractures, are on any specific anti-osteoporotic therapy. These data support the need for more effective education for the community and medical practitioners of the clinical significance of osteoporotic fractures and alternatives for treatment.
在初级保健中,骨质疏松症的认知和治疗水平尚无明确特征。在来自927名初级保健医生处就诊的大量绝经后女性样本数据中,29%的女性报告绝经后发生过一处或多处骨折。绝大多数(72%)未接受任何骨质疏松症特异性治疗。
骨质疏松症通常在低创伤性骨折时首次被发现。然而,到这个阶段,后续骨折的风险已经大幅上升。此外,在许多国家,只有一小部分已经发生骨折的女性接受了能降低进一步骨折风险增加的治疗。
启动该项目以研究澳大利亚绝经后女性骨质疏松性骨折的患病率、骨质疏松症的危险因素以及抗骨折治疗的使用情况。来自927名初级保健医生处的88,000多名女性返回了超过69,358份调查问卷。其中,57,088名报告存在绝经后骨折或危险因素。
在这些随机选取的绝经后女性中,29%报告绝经后发生过一处或多处低创伤性骨折(44%在当前记录中得到证实)。这些女性中有三分之一报告有多处骨折。除肋骨和脚踝骨折外,所有类型骨折的患病率均随年龄增长和体重减轻而增加。报告有骨折的女性也更有可能报告过早绝经、使用过皮质类固醇以及有骨质疏松症家族史。此外有椎体骨折的女性更有可能记录到身高降低、脊柱后凸和背痛。身体活动不足、钙摄入量低和吸烟与任何骨折结果均无一致关联。在报告绝经后发生骨折的女性中,只有28%接受了任何骨质疏松症特异性治疗,7%仅服用钙剂。在那些被医生告知患有骨质疏松症的女性中,40%正在接受特异性骨质疏松症治疗。
在这项针对就诊于初级保健医生的澳大利亚绝经后女性的大型研究中,29%报告绝经后至少发生过一处低创伤性骨折。这些女性中不到三分之一接受了骨质疏松症特异性治疗,只有40%曾被告知患有骨质疏松症。因此,骨质疏松性骨折在澳大利亚绝经后女性中很常见,尽管她们发生进一步骨折的风险大幅增加,但很少有人接受任何特异性抗骨质疏松治疗。这些数据支持需要对社区和医生进行更有效的教育,以了解骨质疏松性骨折的临床意义及治疗选择。