高血压药物治疗的当前概念：噻嗪类利尿剂：关于作用机制的持续思考
Current concepts of pharmacotherapy in hypertension: thiazide-type diuretics: ongoing considerations on mechanism of action.
作者信息
Sica Domenic A
机构信息
Section of Clinical Pharmacology and Hypertension, Division of Nephrology, Box 980160, MCV Station, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298-0160, USA.
出版信息
J Clin Hypertens (Greenwich). 2004 Nov;6(11):661-4. doi: 10.1111/j.1524-6175.2004.03902.x.
Abstract
Thiazide-type diuretics have enjoyed a considerable success in the management of hypertension. These drugs have assumed a standard-of-care position in the minds of many health care providers; however, a number of questions remain unresolved in relation to their use. Such questions include issues of mechanism of action, comparability to loop-diuretics in their actions, class-effect, and the basis for their additivity with non-diuretic antihypertensive medication classes. Understanding these issues is important to the effective use of these compounds.
摘要
噻嗪类利尿剂在高血压治疗方面取得了显著成效。在许多医疗服务提供者的观念中，这类药物已占据标准治疗药物的地位；然而，关于其使用仍存在一些未解决的问题。这些问题包括作用机制、与袢利尿剂作用的可比性、类效应，以及它们与非利尿剂抗高血压药物类别联用的相加作用基础。了解这些问题对于有效使用这些化合物很重要。
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