吲达帕胺与噻嗪类利尿剂治疗原发性高血压患者的比较。

Comparison of indapamide with thiazide diuretics in patients with essential hypertension.

作者信息

Chalmers J P, Bune A J, Graham J R, West M J, Wing L M

出版信息

Med J Aust. 1981 Jul 25;2(2):100-1. doi: 10.5694/j.1326-5377.1981.tb100812.x.

DOI:10.5694/j.1326-5377.1981.tb100812.x

Abstract

The effect of the new diuretic antihypertensive drug, indapamide (2.5 mg a day), was compared with the effect of thiazide diuretics in 24 patients with hypertension (seven of whom were receiving a diuretic alone, six were taking a beta-blocker plus a diuretic, and 11 received other combinations of drugs, including a diuretic in all cases). The randomized crossover study with two six-week phases indicated that indapamide is an effective hypotensive agent with potency similar to that of the thiazide diuretics in lowering the blood pressure and in increasing the excretion of potassium.

摘要

将新型利尿降压药吲达帕胺（每日2.5毫克）的效果与噻嗪类利尿剂的效果在24例高血压患者中进行了比较（其中7例仅接受利尿剂治疗，6例服用β受体阻滞剂加利尿剂，11例接受其他药物组合治疗，所有病例均包括利尿剂）。这项有两个六周阶段的随机交叉研究表明，吲达帕胺是一种有效的降压药，在降低血压和增加钾排泄方面的效力与噻嗪类利尿剂相似。