Hosseini Abolfazl, Ehrén Ingrid, Wiklund N Peter
Department of Urology, Karolinska Hospital, 171 76 Stockholm, Sweden.
J Urol. 2004 Dec;172(6 Pt 1):2261-5. doi: 10.1097/01.ju.0000144761.69398.be.
Nitric oxide (NO) has previously been shown to be a marker for inflammatory disorders in the bladder. We investigated if the measurement of NO can be used to evaluate the treatment response in classic interstitial cystitis (IC).
A total of 15 patients diagnosed with classic IC were included. The patients were treated with oral prednisolone for 8 weeks. We evaluated patient symptoms/problems with the IC index, and we measured NO formation in the bladder.
Seven patients were classified as responders with a 4 point or more decrease in symptom score after 8 weeks of treatment. In this group the mean symptom score was +/- SEM decreased from 15 +/- 1 to 7 +/- 2 at the end of therapy (p <0.05). The problem score was also significantly reduced. Responders showed a clear decrease in bladder NO. The 8 nonresponders did not show any improvement in symptom/problem score and there was no change in bladder NO during steroid treatment. Furthermore, the study showed a statistically significant correlation between changes in symptom/problem score and changes in luminal bladder NO in each patient.
The study shows that NO can be used not only to measure inflammation in patients with IC, but also to evaluate objectively the treatment response in individuals. This makes NO formation a useful marker in the assessment of classic interstitial cystitis.
一氧化氮（NO）此前已被证明是膀胱炎症性疾病的一个标志物。我们研究了测量NO是否可用于评估经典间质性膀胱炎（IC）的治疗反应。
共纳入15例诊断为经典IC的患者。患者接受口服泼尼松龙治疗8周。我们用IC指数评估患者的症状/问题，并测量膀胱中NO的生成。
7例患者被归类为反应者，治疗8周后症状评分降低4分或更多。在该组中，治疗结束时平均症状评分从15±1降至7±2（p<0.05）。问题评分也显著降低。反应者膀胱中的NO明显减少。8例无反应者的症状/问题评分没有任何改善，类固醇治疗期间膀胱NO也没有变化。此外，研究表明每位患者的症状/问题评分变化与膀胱腔内NO变化之间存在统计学上的显著相关性。
该研究表明，NO不仅可用于测量IC患者的炎症，还可客观评估个体的治疗反应。这使得NO生成成为评估经典间质性膀胱炎的一个有用标志物。
