Maron Eduard, Kuikka Jyrki T, Ulst Kai, Tiihonen Jari, Vasar Veiko, Shlik Jakov
Dept. of Psychiatry, University of Tartu, Raja 31, Tartu 50417, Estonia.
Eur Arch Psychiatry Clin Neurosci. 2004 Dec;254(6):392-6. doi: 10.1007/s00406-004-0520-3. Epub 2004 Nov 12.
The purpose of this study was to characterize the binding properties of serotonin transporter (5-HTT) in the brain of the patients with generalized anxiety disorder (GAD) in comparison to healthy subjects using single photon emission computer tomography (SPECT) with the radioligand [123I]nor-beta-CIT. The subjects were 7 patients with GAD and 7 matched healthy volunteers. The regions of interest (ROI) were the midbrain and the thalamus. The comparison of the volumes of distribution did not show significant differences between the patients and controls in the binding of nor-beta-CIT to 5-HTT in the ROI. Binding of 5-HTT in the midbrain of patients was significantly and negatively correlated with their anxiety levels measured by the visual analogue scale immediately before the first scan (r=-0.79, p=0.035). This study failed to demonstrate an altered functional activity of 5-HTT in patients with GAD when compared with controls.
本研究的目的是，通过使用放射性配体[123I]去甲-β-羧基-3β-(4-碘苯基)托烷的单光子发射计算机断层扫描（SPECT），比较广泛性焦虑症（GAD）患者与健康受试者大脑中5-羟色胺转运体（5-HTT）的结合特性。受试者包括7名GAD患者和7名匹配的健康志愿者。感兴趣的区域（ROI）是中脑和丘脑。分布体积的比较未显示患者与对照组在ROI中去甲-β-羧基-3β-(4-碘苯基)托烷与5-HTT结合方面存在显著差异。患者中脑5-HTT的结合与首次扫描前通过视觉模拟量表测量的焦虑水平显著负相关（r=-0.79，p=0.035）。与对照组相比，本研究未能证明GAD患者的5-HTT功能活性发生改变。
