Juonala Markus, Viikari Jorma S A, Kähönen Mika, Taittonen Leena, Rönnemaa Tapani, Laitinen Tomi, Mäki-Torkko Noora, Mikkilä Vera, Räsänen Leena, Akerblom Hans K, Pesonen Erkki, Raitakari Olli T
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.
Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):392-8. doi: 10.1161/01.ATV.0000150042.43866.7f. Epub 2004 Nov 11.
People living in eastern Finland have approximately 40% higher coronary heart disease mortality rates than western Finns. Whether this is because of genetic or environmental factors is unknown. We examined the effect of geographic family origin on subclinical atherosclerosis among young Finns.
As part of a longitudinal follow-up study, we measured carotid intima-media thickness (IMT) in 2264 and brachial flow-mediated dilation (FMD) in 2109 white adults, aged 24 to 39 years. Subjects from eastern Finland had greater IMT and lower FMD compared with western subjects. These differences accentuated when the subjects' family origin (grandparents' birthplace) was taken into account and remained significant after adjusting for several environmental factors. Among subjects with all grandparents born in eastern or western Finland, IMTs were (mean+/-SEM) 0.592+/-0.003 versus 0.565+/-0.005 mm (P<0.0001), respectively. The corresponding FMD values were 7.61+/-0.15% versus 8.75+/-0.26%; P<0.01. The number of grandparents born in eastern Finland was directly related to IMT (P<0.0001) and inversely to FMD (P<0.05).
Young adults originating from eastern Finland have greater carotid IMT and lower brachial FMD than western Finns. Consistent with a hereditable component predisposing to or protecting from atherosclerosis, these differences accentuated when subjects' family origin was taken into account. We studied whether an east-west difference exists in markers of subclinical atherosclerosis in 2264 Finns aged 24 to 39 years. Subjects with family origin in eastern Finland had greater carotid IMT and lower brachial FMD compared with western subjects, suggesting that hereditable factors play a role in excess atherosclerosis risk in eastern Finland.
生活在芬兰东部的人群冠心病死亡率比芬兰西部人群高约40%。这是由于遗传因素还是环境因素尚不清楚。我们研究了地理家族起源对年轻芬兰人亚临床动脉粥样硬化的影响。
作为一项纵向随访研究的一部分，我们测量了2264名24至39岁白人成年人的颈动脉内膜中层厚度（IMT）以及2109名白人成年人的肱动脉血流介导的血管舒张功能（FMD）。与西部受试者相比，来自芬兰东部的受试者IMT更大，FMD更低。当考虑受试者的家族起源（祖父母出生地）时，这些差异更加明显，并且在调整了几个环境因素后仍然显著。在所有祖父母均出生于芬兰东部或西部的受试者中，IMT分别为（均值±标准误）0.592±0.003与0.565±0.005毫米（P<0.0001）。相应的FMD值分别为7.61±0.15%与8.75±0.26%；P<0.01。出生于芬兰东部的祖父母数量与IMT呈正相关（P<0.0001），与FMD呈负相关（P<0.05）。
与芬兰西部的年轻人相比，来自芬兰东部的年轻人颈动脉IMT更大，肱动脉FMD更低。考虑受试者的家族起源时，这些差异更加明显，这与遗传因素在动脉粥样硬化易感性或保护性方面的作用一致。我们研究了2264名24至39岁芬兰人亚临床动脉粥样硬化标志物是否存在东西方差异。与西部受试者相比，家族起源于芬兰东部的受试者颈动脉IMT更大，肱动脉FMD更低，这表明遗传因素在芬兰东部动脉粥样硬化风险过高方面起作用。
